Church Dwight & Co., Inc.

Noah Paul Zimmerman

Amy Wescott

Alexandra Smith

Compositions and methods for converting at least one polyphenol to protocatechuic acid (PCA) using1579, or active variants thereof, are provided. Conversion of polyphenols, such as quercetin, to PCA can decrease inflammation, decrease cortisol levels, and increase milk quality and milk production quantity in milk-producing agricultural animals. Accordingly, provided herein are compositions comprising1579, or an active variant thereof, for administration to humans for decreasing inflammation or for administration to milk-producing agricultural animals for decreasing inflammation, decreasing cortisol levels, and increasing milk quality and milk production.

Microbial compositions to increase the production of PCA from polyphenols

The present invention relates to microbial compositions containing, and methods for reducing growth of microbes that cause infection, such as urogenital tract infection and for treating or preventing the same using the compositions thereof.

compositions and methods for prevention and treatment of microbial infection

Compositions and methods for converting at least one glucosinolate to an isothiocyanate using839,CO4_4,M3_H01, and/orM2_H12, or active variants thereof, are provided. Conversion of glucosinolates, such as glucoraphanin, to isothiocyanates, such as sulforaphane, leads to the stimulation of the Nrf2/Keap pathway and phase II enzymes, providing chemoprotective and anti-inflammatory effects. Accordingly, provided herein are compositions comprising839,CO4_4,M3_H01, and/orM2_H12, or active variants thereof, for administration to subjects for increasing isothiocyanate (e.g., sulforaphane) production, increasing the expression of genes regulated by the Nrf2 transcription factor, including phase II enzymes, decreasing inflammation, and treating or preventing an inflammatory disorder or a cancer. The composition can comprise at least one glucosinolate or a plant, plant part or an extract thereof comprising glucosinolate(s).

Growing community of inventors

Chapel Hill, NC, United States of America

Noah Paul Zimmerman