Arbor Biotechnologies, Inc.

Noah Michael Jakimo

Quinton Norman Wessells

Tia Marie Ditommaso

Sejuti Sengupta

Jeffrey Raymond Haswell

Shaorong Chong

Anthony James Garrity

Lauren E Alfonse

Roy Ziblat

The present disclosure relates to variant polypeptides, methods of preparing the variant polypeptides, processes for characterizing the variant polypeptides, compositions and cells comprising the variant polypeptides, and methods of using the variant polypeptides. The disclosure further relates to complexes comprising the variant polypeptides, methods of producing the complexes, processes for characterizing the complexes, cells comprising the complexes, and methods of using the complexes.

Compositions comprising a CRISPR nuclease and uses thereof

Provided herein are gene editing systems and/or compositions comprising RNA guides targeting LDHA for use in genetic editing of the LDHA gene. Also provide herein are methods of using the gene editing system for introducing edits to the LDHA gene and/or for treatment of primary hyperoxaluria (PH), and processes for characterizing the gene editing system.

Gene editing systems comprising an RNA guide targeting lactate dehydrogenase a (LDHA) and uses thereof

Provided herein are gene editing systems and/or compositions comprising RNA guides targeting HAO1 for use in genetic editing of the HAO1 gene. Also provide herein are methods of using the gene editing system for introducing edits to the HAO1 gene and/or for treatment of primary hyperoxaluria (PH), and processes for characterizing the gene editing system.

Gene editing systems comprising an RNA guide targeting hydroxyacid oxidase 1 (HAO1) and uses thereof

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San Francisco, CA, United States of America

Noah Michael Jakimo