Minovia Therapeutics Ltd.

Noa Sher

Uriel Halavee

Shmuel Bukshpan

Natalie Yivgi Ohana

Moriya Blumkin

The present invention provides human stem cells enriched with functional mitochondria, wherein the healthy functional exogenous mitochondria constitute at least 3% and less than 33% of the total mitochondria in the mitochondrially-enriched human stem cells. Further disclosed are methods for the production of such cells, and uses thereof for the treatment of primary mitochondrial diseases.

Mitochondrial augmentation therapy for primary mitochondrial diseases

The present invention provides stem cells enriched with healthy functional mitochondria, pharmaceutical compositions comprising these cells and methods of use thereof for treating brain diseases, disorders and symptoms thereof where the disease may or may not be associated with acquired mitochondrial dysfunction.

Mitochondrial augmentation therapy of brain diseases

The present invention provides stem cells enriched with healthy functional mitochondria, pharmaceutical compositions comprising these cells and methods of use thereof for treating renal diseases, disorders and symptoms thereof where the disease may or may not be associated with acquired mitochondrial dysfunction.

Mitochondrial augmentation therapy of renal diseases

The present invention provides stem cells enriched with healthy functional mitochondria, pharmaceutical compositions comprising these cells and methods of use thereof for treating ocular diseases, disorders and symptoms thereof where the disease may or may not be associated with acquired mitochondrial dysfunction.

Mitochondrial augmentation therapy of ocular diseases

The present invention provides stem cells enriched with healthy functional mitochondria, pharmaceutical compositions comprising these cells and methods of use thereof for treating muscle diseases, disorders and symptoms thereof where the disease may or may not be associated with acquired mitochondrial dysfunction.

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Haifa, Israel

Noa Sher