Merck Sharp + Dohme Corp.

Njamkou Noucti

Matthew G Stanton

David L Sloman

Jongwon Lim

Michael D Altman

Benito Munoz

Alan B Northrup

Jason David Katz

James Patrick Jewell

Sandra Lee Knowles

Brandon Mitsuo Taoka

Sandra Lee

Sandra L Knowles

David J Sloman

The invention encompasses pyrazolo[1,5-a]pyrimidine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included.

Pyrazolo[1,5-A]pyrimidines as mark inhibitors

The invention encompasses pyrazolo[1,5-a]pyridine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included.

Pyrazolo[1,5-a]pyridines as MARK inhibitors

Compounds of the following formula (I) are inhibitors of microtubule affinity regulating kinase, and hence find use in the treatment of neurodegenerative diseases associated with hyperphosphorylation of tau. 

Pyrazolo[1,5-a]pyrimidine derivatives

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Carrboro, NC, United States of America

Njamkou Noucti