University of Central Florida Research Foundation Inc

Other

Nizam Razack

Richard D Gilson

Gregory Francis Welch

In one embodiment, a system for stimulating neurons of a patient in vivo is provided herein. The system includes a first energy emitting component positioned external to the patient configured to generate a first energy stimulus, and a second energy emitting component positioned external to the patient configured to generate a second energy stimulus, wherein the first energy stimulus comprises an intensity level below a predetermined threshold required to stimulate the neurons, and wherein the second energy stimulus comprises an intensity level below a predetermined threshold required to stimulate the neurons; wherein a combination of the first and second energy stimuli at a target location in a target tissue of a patient comprises an intensity level at or above a predetermined threshold required to stimulate the neurons in the target tissue and prevent the stimulation of neurons outside the target location.

Non-invasive in vivo deep nerve cell stimulation system and method

Methods, systems, and devices for a deep brain stimulation device using miniaturized components that allow integration with the implanted probe, and includes a skull-sited housing having all the controls and battery power supply for sensing events and generating and transmitting pulses in response to the sensed event. A processor based controller with memory within the skull-sited housing for executing monitoring instructions for sensing initiation of an unwanted electro-physiologically signaled event and recording the event in memory and triggering instructions for activating the stimulator to generate and record a treatment pulse in response to the sensed event and an interface between the processor based controller and a treatment provider for downloading the recorded event and treatment response and modifying the monitoring and triggering sets of instructions.

Spatial-temporal deep brain stimulation methods and systems

Methods, systems and devices to provide correction parameters for implanted electrodes by applying a cathode pulse to a bilateral implanted electrode while providing a synchronized anode on the opposite electrode. The electrical field can be 'shaped' over space and time to reach more of the targeted area by selecting various combinations of active contacts. The cathode lead directs the electrical field to the target and the placement and number of anode contacts activated determines the electric field path and rate of dissipation based on vertical and horizontal distance and timing. The correction parameter can be applied to anode and cathode contacts on a single implanted lead. Each lead can have plural anode and cathode contacts each independently controllable. Active anodes and cathodes are statically or dynamically selected to generate a shaped electric field to reach the target.

Methods for electronic directionality of deep-brain stimulation

Methods, systems, and devices to reduce power demands substantially for current deep brain stimulation DBS using smart technology type applications. The invention uses miniaturized components that allow integration with the implanted probe(s) themselves, and includes a skull-sited housing having all the controls and battery power supply needed. This avoids implanting obtrusive card-deck size batteries in the chest area and the use of vulnerable wire leads under the skin from the chest area to connect with the implanted electrode(s) on the skull, improving comfort. The Generating of non-continuous pulses on demand of conditions such as the occurrence of a tremor occurs, without having to continuously run pulses at all times, substantially increasing life spans over current techniques. Shaped electrodes and their methods further reduce power demands and efficacy by directing electric fields to focus towards specific areas and regions of the brain rather than inefficient 360-degree emission.

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Orlando, FL, United States of America

Nizam Razack