Berg LLC

University of Miami

Bpgbio, Inc.

Other

The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

Berg Pharma LLC

Niven Rajin Narain

Rangaprasad Sarangarajan

John Patrick McCook

Shiv Srivastava

Sylvia Daunert

Vivek Kannoth Vishnudas

Indushekhar Persaud

John Patrick Mccook

Joaquin J Jimenez

Sung Lan Hsia

Viatcheslav R Akmaev

Sapna K Deo

Karrune Veeraprasert Woan

Enxuan Jing

Jie Li

Kathryn J Russell

Stephane Gesta

Michael Andrew Kiebish

Nikunj Narendra Tanna

Shen Luan

Thomas Mitchell Gray

Vivek K Vishnudas

Min Du

Tony Walshe

Albert Dobi

Emre Dikici

Vijetha Vemulapalli

Jennifer Cullen

Eric Milliman

Paula Patricia Narain

Jeremy Chaufty

Leonardo Rodrigues

Reinhard Roessler

Anne R Diers

Lixia Zhang

Pirouz Mohammad Daftarian

Paul Y Song

Sung L Hsia

Patrick Mccook John

Joaquin Juan Jimenez

Kathryn J Rusell

Methods for identifying a modulator of angiogenesis and methods for modulating angiogenesis in a mammalian subject are described herein. In some embodiments, the methods include obtaining data sets from a model for angiogenesis and generating a causal relationship network model based on the obtained data. In some embodiments, the methods include identifying, from the causal relationship network model, a causal relationship unique in angiogenesis, where a gene, lipid, protein, metabolite, transcript, or SNP associated with the unique causal relationship is identified as a modulator of angiogenesis.

Interrogatory cell-based assays and uses thereof

Methods for diagnosing the presence of BCR in prostate cancer in a subject are provided, such methods including the detection of levels of a variety of biomarkers diagnostic of BCR. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.

Markers for the diagnosis of biochemical recurrence in prostate cancer

The invention provides methods and compositions for treatment of a subject with a glioma that has failed treatment with temozolomide (TMZ) comprising administration of a composition comprising a Coenzyme Q10 compound to the subject. The invention also provides a method of treating a cancer that exhibits increased Complex II activity in a subject comprising administration of a composition comprising a Coenzyme Q10 compound to the subject.

Methods of treatment of temozolomide-resistant glioma using coenzyme Q10

Methods and formulations for treating oncological disorders in humans using Coenzyme Q10 are described.

Methods for treatment of oncological disorders using an epimetabolic shifter (coenzyme Q10)

Systems, methods, and computer-readable medium are provided for healthcare analysis. Data corresponding to a plurality of patients is received. The data is parsed to generate normalized data for a plurality of variables, with normalized data generated for more than one variable for each patient. A causal relationship network model is generated relating the plurality of variables based on the generated normalized data using a Bayesian network algorithm. The causal relationship network model includes variables related to a plurality of medical conditions or medical drugs. In another aspect, a selection of a medical condition or drug is received. A sub-network is determined from a causal relationship network model. The sub-network includes one or more variables associated with the selected medical condition or drug. One or more predictors for the selected medical condition or drug are identified.

Bayesian causal relationship network models for healthcare diagnosis and treatment based on patient data

Described herein is a discovery Platform Technology for analyzing a drug-induced toxicity condition, such as cardiotoxicity via model building.

Interrogatory cell-based assays for identifying drug-induced toxicity markers

Described herein is a discovery Platform Technology for analyzing a biological system or process (e.g., a disease condition, such as cancer) via model building.

The invention provides methods and compositions for treatment of a subject with a central nervous system (CNS) tumor comprising administration of Coenzyme Q10 (CoQ10), particularly when the subject exhibits at least one CNS abnormality as a result of the tumor.

Method of treating or preventing tumors of the central nervous system

The present invention is directed, in part, to methods of treating Epidermolysis Bullosa (EB) in a subject in need thereof, comprising topical administration of a pharmaceutical composition comprising a therapeutically effective amount of a of Coenzyme Q10 (CoQ10) to the subject.

Use of coenzyme Q10 formulations in the treatment and prevention of epidermolysis bullosa

Disclosed herein are formulations suitable for parenteral administration of certain hydrophobic active agents such as Coenzyme Q10. Methods of preparing the same and methods of treatment of oncological disorders using the same are also provided herein. The formulations comprise an aqueous solution; a hydrophobic active agent dispersed to form a colloidal nano-dispersion of particles; and at least one of a dispersion stabilizing agent and an opsonization reducer wherein the colloidal nano-dispersion of the active agent is dispersed into nano-dispersion particles having a mean size of less than 200-nm. Methods of preparing the parenteral formulations comprise dispersing the hydrophobic active agent by high pressure homogenization by (1) adding hydrophobic active agent to a 65&#xb0; C. bath of water and mixing to form a hydrophobic active agent/water mixture; (2) adding a dispersion stabilizing agent to the hydrophobic active agent/water mixture and mix at 65&#xb0; C. to form a hydrophobic active agent/water/stabilizer mixture; (3) adding an opsonization reducer to form a hydrophobic active agent/water/stabilizer/reducer mixture; (4) pre-heating a Microfluidizer to 65&#xb0; C.; and (5) processing by mixing the hydrophobic active agent/water/stabilizer/reducer mixture in the Microfluidizer at 65&#xb0; C. such that a hydrophobic active agent colloidal nano-dispersion having a mean particle size less than 200-nm is formed. Provided herein are also methods of treating oncological disorders by administering formulations described herein to a subject such that treatment or prevention of the oncological disorder occurs.

Intravenous formulations of coenzyme Q10 (CoQ10) and methods of use thereof

The invention provides methods and pharmaceutical compositions for preventing or treating alopecia, such as chemotherapy-induced alopecia (CIA). The pharmaceutical compositions of the invention comprises an effective amount of a vitamin D compound in a formulation that topically delivers the vitamin D compound to the epidermis layer but substantially avoids the dermis layer. In chemotherapy patients, the pharmaceutical compositions of the invention can be administered either before or concurrent with the chemotherapy medication.

Vitamin D3 and analogs thereof for treating alopecia

The invention provides regimens and methods for the treatment of cancer comprising continuous infusion of coenzyme Q10. The coenzyme Q10 may be administered as a monotherapy, or in combination with an additional agent, such as an anticancer agent, a chemotherapeutic agent, or an anti-angiogenic agent. The coenzyme Q10 may be administered at two or more different rates.

Methods of treatment of cancer by continuous infusion of coenzyme Q10

The invention provides compositions comprising Eno1 for delivery to a muscle. Further, the invention provides a method for normalizing blood glucose in a subject with elevated blood glucose, comprising administering to the subject enolase 1 (Eno1), thereby normalizing blood glucose in the subject. The invention also provides methods of treating one or more conditions including impaired glucose tolerance, insulin resistance, pre-diabetes, and diabetes, especially type 2 diabetes in a subject, comprising administering to the subject enolase 1 (Eno1), thereby treating the condition in the subject. In certain methods of the invention, the Eno1 is delivered to muscle.

Enolase 1 (ENO1) compositions and uses thereof

The invention provides methods for rapid and quantitative extraction and detection of coenzyme Q10 in a sample readily adaptable to high throughput screening methods. The invention further provides reagents and kits for practicing the methods of the invention.

Methods and kits for detection of coenzyme Q10

Growing community of inventors

Cambridge, MA, United States of America

Niven Rajin Narain