Arqule, Inc.

Nivedita Namdev

Jean-Marc Lapierre

Manish Tandon

Mark Anthony Ashwell

Rocio Palma

Jason J Hill

Yanbin Liu

David Vensel

Anton Filikov

Jianqiang Wang

Sudharshan Eathiraj

Neil Westlund

Chris Brassard

Syed M Ali

Robert B Nicewonger

Rui-Yang Yang

Brian Schwartz

Kiyoshi Nakayama

Hui Wu

Yusuke Ota

Akihisa Matsuda

Hiroaki Inagaki

Shin Iimura

Takayuki Momose

Steffi Koerner

Tomoyuki Tsunemi

Audra Dalton

Jeffrey Link

Takeshi Isoyama

Kenichi Yoshida

Takahiro Kitamura

Eugene W Kelleher

Yuko Yamamoto

Takanori Yamazaki

Robert Nicewonger

Mark A Ashwell

Magdi Moussa

Dennis S France

Patrick M Hutchins

Jeff S Link

Robb B Nicewonger

Rebecca J Carazza

Eugene Kelleher

Jason Hill

Mark Ashwell

The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, tautomer, prodrug, solvate, metabolite, polymorph, analog or derivative thereof, which modulates the activity of BTK, a pharmaceutical composition comprising the compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.

Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof

The present invention relates to substituted tricyclic pyrazolo-pyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted tricyclic pyrazolo-pyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Substituted tricyclic pyrazolo-pyrimidine compounds

The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Substituted imidazopyridinyl-aminopyridine compounds

The present invention relates to substituted pyrazolo-pyrrolo-pyridine-dione compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted pyrazolo-pyrrolo-pyridine-dione compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.

Substituted pyrazolo-pyrrolo-pyridine-dione compounds

The present invention relates to substituted imidazopyridinyl compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Substituted imidazopyridinyl compounds

The present invention relates to substituted pyrrolo-aminopyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted pyrrolo-aminopyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof. The substituted pyrrolo-aminopyrimidine compounds have the following general formula: 

Substituted pyrrolo-aminopyrimidine compounds

The present invention relates to pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound or pyrrolidine-2,5-dione compound of the present invention. (Ia) (Ib) (IIa) (IIIb) Where U is independently selected from: (I) or (II) where U is independently selected from: 

Compositions and methods for the treatment of cancer

The present invention relates to substituted indolo-pyridinone compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted indolo-pyridinone compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.

Substituted indolo-pyridinone compounds

The present invention relates to substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds

The present invention relates to substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Substituted dipyrido-pyrimido-diazepine and benzo-pyrido-pyrimido compounds

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Westford, MA, United States of America

Nivedita Namdev