Cytiva Sweden Ab

General Electric Company

Nityananda Maiya

Klaus Gebauer

Prashanth Hosabettu Mohan

Deepak Aravind

Ajit S Vernekar

Nachiket Karmarkar

Sasi Kumar Nutalapati

Shivakumar Selvaraj

Sameera Simha Hindupur

Shashidhar Hedge

Saameera Simha Hindupur

Fredrik Lundström

Alagur Sahebagouda

Sasikumar Arumugam

Sudheer Mygapula

Jithin Thattari Kandiyil

Bashkar Hv

The invention discloses a method of controlling a transmembrane pressure (TMP) in a crossflow filtration apparatus, comprising the steps of: a) providing a crossflow filtration apparatus comprising a pump () fluidically connected via a retentate compartment () of a crossflow filter () and a length of flexible tubing to a regulator valve (1; 101) acting on the flexible tubing, wherein the regulator valve is a high precision pinch valve. The apparatus further comprises a first pressure transducer () adapted to measure a pressure between the retentate compartment and the regulator valve, a second pressure transducer () adapted to measure a pressure between the pump and the retentate compartment and a third pressure transducer () adapted to measure a pressure at a permeate outlet () of the crossflow filter, and a control unit () electrically or electromagnetically connected to said regulator valve, the first, second and third pressure transducers and optionally to the pump; b) pumping a liquid with the pump via the second pressure transducer, through the retentate compartment via the length of flexible tubing, the first pressure transducer and the regulator valve; c) controlling the regulator valve with the control unit, such that a TMP calculated by formula (I) TMP=(P+P)/2−Pcorresponds to a predetermined TMP value or to an interval between two predetermined TMP values, wherein Pis a pressure reading from the second pressure transducer, Pis a pressure reading from the first pressure transducer and Pis a pressure reading from the third pressure transducer.

Method for pressure control in crossflow filtration

A method includes measuring, by a flow sensor (), a flow rate of a permeate fluid () flowing through a filter () of a membrane filtration system (). Further, the method includes receiving, by a control unit (), the measured flow rate of the permeate fluid () and determining, by the control unit (), a first flux rate of the filter () based on the measured flow rate of the permeate fluid (). Furthermore, the method includes comparing, by the control unit (), the determined first flux rate with a first predetermined flux rate. Additionally, the method includes operating the membrane filtration system (), by the control unit (), in a normal mode or a flux tolerant mode based on the comparison of the determined first flux rate with the first predetermined flux rate. The flux tolerant mode of the membrane filtration system () is further based on a determined normalized water permeability value of the filter ().

System for filtration and associated method

An ultrasound probe diagnosing apparatus for diagnosing an ultrasound probe having a probe head comprising a plurality of transducer elements is disclosed. The ultrasound probe diagnosing apparatus includes a reflective interface configured to reflect ultrasonic signals transmitted from a transducer element of the plurality of transducer elements. The reflected ultrasonic signals are received by at least one transducer element present in the probe head. A probe diagnosis unit is communicably coupled to the plurality of transducer elements. The probe diagnosis unit is configured to analyze at least one signal parameter associated with the reflected ultrasonic signals received for diagnosing performance of the transducer element.

Ultrasound probe diagnosing system and method for diagnosing ultrasound probe

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Bengaluru, India

Nityananda Maiya