Johns Hopkins University

Infinite Biomedical Technologies, LLC

Other

The United States of America As Represented by the Secretary of

Ikona Medical Corporation

Nitish V Thakor

Ananth Natarajan

Stuart D Harshbarger

R Jacob Vogelstein

Santosh Venkatesha

Jeffrey M Wallace

Abhishek Rege

Kartikeya Murari

Keith Peacock

Nan Li

James D Beaty

Janaka Senarathna

Feras Al Hatib

David H Sherman

James Duncan Beaty

Girish Singhal

Hongxuan Zhang

Anastasios Bezerianos

Hasan Al-Nashash

Abhiskek Rege

Joseph Paul

Shanbao Tong

Christopher L Christman

Rahul R Kaliki

Dominic Cheung

Arvind Pathak

Neha Malhotra

Hang Yu

An embodiment in accordance with the present invention provides a miniature microscope capable of performing in vivo, real-time imaging of multiple organ sites in awake and behaving animals (e.g. rodents). A microscope according to the present invention includes multiple optical contrast mechanisms (i.e. contrast arising from neural, hemodynamic and other physiological components). Exemplary contrast mechanisms include, but are not limited to fluorescence, hemoglobin level, deoxyhemoglobin level, and blood flow. The microscope is fully adaptable to in vitro and ex vivo imaging, can be customized to concurrently image at variable magnifications, conduct optogenetic/electrical/chemical stimulations, drug delivery, microdialysis, accompanied by electrical signal recording, wireless image transmission and charging.

Miniature microscope for multi-contrast optical imaging in animals

Methods and systems to interface between physiological devices and a prosthetic device, including to receive a plurality of types of physiological activity signals from a user, decode a user movement intent from each of the plurality of signals types, and fuse the movement intents into a joint decision to control moveable elements of the prosthetic device.

Multi-modal neural interfacing for prosthetic devices

A system for multimodal laser speckle imaging may include a first light source positioned to emit laser light toward a target, a second light source positioned to emit light toward the target, a camera positioned to receive light scattered from the target, and a processor. The processor may be programmed to receive from the at least one camera at least one image of the target as illuminated by the laser, obtain a laser speckle contrast image of the target from the at least one image of the target as illuminated by the laser, receive from the at least one camera at least one image of the target as illuminated by the second light source, divide the laser speckle contrast image into subparts, and divide the at least one image of the target as illuminated by the second light source into identical subparts, determine whether each subpart includes a feature of a certain type by combining each subpart of the laser speckle contrast image with the at least one image of the target as illuminated by the second light source and comparing the combination with one or more criteria, and out-putting the location and type of features detected in a subpart of the images.

Multimodal laser speckle imaging

An embodiment in accordance with the present invention provides a system and method for imaging living tissue and processing laser speckle data anisotropically to calculate laser speckle contrast preferentially along the direction of blood flow. In the present invention, raw laser speckle images are obtained and processed resulting in the anisotropic laser speckle images. The system and method involve the determination of the direction of blood flow for every pixel within the region of interest (primary pixel) and subsequent extraction of a set of secondary pixels in the spatio-temporal neighborhood of the primary pixel that is anisotropic in the direction of blood flow. Speckle contrast is then calculated for every primary pixel as the ratio of standard deviation and mean of all secondary pixels in this anisotropic neighborhood and collectively plotted using a suitable color mapping scheme to obtain an anisotropic laser speckle contrast image of the region of interest.

Anisotropic processing of laser speckle images

A system for multimodal laser speckle imaging may include a first light source positioned to emit laser light toward a target, a second light source positioned to emit light toward the target, a camera positioned to receive light scattered from the target, and a processor. The processor may be programmed to receive from the at least one camera at least one image of the target as illuminated by the laser, obtain a laser speckle contrast image of the target from the at least one image of the target as illuminated by the laser, receive from the at least one camera at least one image of the target as illuminated by the second light source, divide the laser speckle contrast image into subparts, and divide the at least one image of the target as illuminated by the second light source into identical subparts, determine whether each subpart includes a feature of a certain type by combining each subpart of the laser speckle contrast image with the at least one image of the target as illuminated by the second light source and comparing the combination with one or more criteria, and outputting the location and type of features detected in a subpart of the images.

One embodiment enables detection of MI/I and emerging infarction in an implantable system. A plurality of devices may be used to gather and interpret data from within the heart, from the heart surface, and/or from the thoracic cavity. The apparatus may further alert the patient and/or communicate the condition to an external device or medical caregiver. Additionally, the implanted apparatus may initiate therapy of MI/I and emerging infarction.

Implantable myocardial ischemia detection, indication and action technology

An assembly may include a plurality of electrode contacts adapted to receive myoelectric signals from a body when placed into contact with the body. The assembly may also include a support structure adapted to support the electrode contacts. The assembly may also include a prosthetic liner, the support structure being embedded in the prosthetic liner. The electrode contacts may be positioned to be extending through openings in the prosthetic liner. The assembly may also include signal processing circuitry adapted to process the myoelectric signals from the body. Other embodiments are described and claimed.

Electrode assemblies for detecting muscle signals in a prosthetic liner

Embodiments include devices and methods. One embodiment includes a method for imaging an endometrial cavity, including acquiring a plurality of images using an imaging system. A first part of the imaging system is positioned within the endometrial cavity. At least portions of two or more of the images are combined into a representation of at least a portion of the endometrial cavity. The combining at least portions of two of the images may include determining any motion of the first part of the imaging system, between the two or more of the images. Other embodiments are described and claimed.

Methods and devices for endoscopic imaging

Certain embodiments include an endoscope and methods for imaging using the endoscope. The endoscope may include an imaging channel and a tip positioned at one end of the imaging channel, the tip adapted to collect light from a field of view that extends 360&#xb0; around at least a portion of the endoscope and to transmit the light to the imaging channel. Certain embodiments may also utilize various sensors, controllers and processing mechanisms to record and process images into a representation, move the endoscope in and out of the endometrial cavity, and to biopsy a portion of the endometrium.

Endoscopic imaging of an organ system

Methods for identifying and extracting heart depolarization and repolarization in a paced heart. Certain methods also include identifying and analyzing particular features of at least one pacing spike and QRS waveform for heart beat characterization. These features may include signal changing speed and signal time interval (distance) of pacing spikes and QRS depolarization when pacing excitation is initialized.

Method of extracting and evaluating paced heart beats using max-min transform analysis

Embodiments include methods and apparatus for determining whether a neurological event has occurred in a subject. An apparatus includes at least one sensor adapted to sense electroencephalogram signals from the subject. The apparatus also includes an electroencephalogram acquisition module adapted to receive the electroencephalogram signals from at least one sensor, and a processing and analysis module adapted to receive signals from the electroencephalogram acquisition module and determine changes in neurological function using entropy analysis.

Apparatus and methods for brain rhythm analysis

An implantable apparatus may include a plug member having a lumen and a valve adapted to open and close the lumen in response to a signal. The apparatus may also include at least one sensor and a controller adapted to control the valve. The controller may be programmable to open the valve to permit the flow of urine under at least one mode of operation selected from a predetermined time interval operation, a sensor operation, and a manual actuation operation.

Growing community of inventors

Clarksville, MD, United States of America

Nitish V Thakor