The University of Texas System

Nitin Tandon

Kiefer Forseth

Christopher R Conner

Patrick Sarahan Rollo

Cristian Donos

Cihan Mehmet Kadipasaoglu

Kevin Pham

Thomas A Pieters

Mehmet Kadipasaoglu

A method includes obtaining a first imaging scan and a second imaging scan of a single subject brain. The first imaging scan is converted to a first dataset, and the second imaging scan is converted to a second dataset. A sequence-adaptive multimodal segmentation algorithm is applied to the first dataset and the second dataset. The sequence-adaptive multimodal segmentation algorithm performs automatic intensity-based tissue classification to generate a first labelled dataset and a second labeled dataset. The first labeled dataset and the second labeled dataset are automatically co-registered to each other to generate a transformation matrix based on the first labeled dataset and the second labeled dataset. The transformation matrix is applied to align the first dataset and the second dataset.

Methods for optimizing the planning and placement of probes in the brain via multimodal 3D analyses of cerebral anatomy

This invention relates generally to methods for localization and visualization of implanted electrodes and penetrating probes in the brain in 3D space with consideration of functional brain anatomy. Particularly, this invention relates to precise and sophisticated methods of localizing and visualizing implanted electrodes to the cortical surface and/or topological volumes of a patient's brain using 3D modeling, and more particularly to methods of accurately mapping implanted electrodes to the cortical topology and/or associated topological volumes of a patient's brain, such as, for example, by utilizing recursive grid partitioning on a manipulable virtual replicate of a patient's brain. This invention further relates to methods of surgical intervention utilizing accurate cortical surface modeling and/or topological volume modeling of a patient's brain for targeted placement of electrodes and/or utilization thereof for surgical intervention in the placement of catheters or other probes into it.

Methods for localization and visualization of electrodes and probes in the brain using anatomical mesh models

This invention relates generally to systems and methods for multifocal direct brain stimulation to enhance cognitive processing, such as but not limited to stimulation-induced modulation of memory.

Systems and methods for network based neurostimulation of cognitive processes

Subdural electrode localization and visualization using parcellated, manipulable cerebral mesh models

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Houston, TX, United States of America

Nitin Tandon