Wockhardt Limited

Nitin Shetty

Mahesh Vithalbhai Patel

Noel John De Souza

Ravindra Dattatraya Yeole

Prasad Keshav Deshpande

Milind Chintaman Shukla

Yati Chugh

Shrikant V Gupte

Shivkumar Agarwal

Satish B Bhawsar

Milind Dattatraya Sindkhedkar

Dilip J Upadhyay

Rupinder K Beri

Sachin Subhash Bhagwat

Nishith Chandra Chaturvedi

Habil Fakhruddin Khorakiwala

Sreenivas Kandepu

Mahesh Shriram Phansalkar

Abraham Thomas

Shiv Kumar Agarwal

Kandepu Sreenivas

Sheela Chandrasekharan Nair

Noel J De Souza

M Madhav Reddy

Shrikant Vinayak Gupte

The present invention provides agents having antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel substituted piperidino phenyloxazolidinone derivatives, processes for making compounds as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.

Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy

The present invention provides agents having high antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel cyano-(substituted)-methylenepiperidinophenyl oxazolidinone derivatives, processes for making the compounds, as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.

Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoprotein sites

The present invention relates to optically pure S-(&#x2212;)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof, substantially free of their R-(+)-isomers, to processes for preparation of the optically pure S-(&#x2212;)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof substantially free of their R-(+)-isomers, and to pharmaceutical compositions comprising the S(&#x2212;)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof.

Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment

This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments

The invention relates to the new arginine salt forms of S-(&minus;)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo&lsqb;i,j&rsqb;quinolizine-2-carboxylic acid, a process for their preparation and pharmaceutical formulations which comprise those arginine salt forms as the active ingredient for its use in treating antimicrobial infections.

Chiral fluoroquinolone arginine salt forms

The present invention relates to optically pure S-(&minus;)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof, substantially free of their R-(&plus;)-isomers, to processes for preparation of the optically pure S-(&minus;)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof substantially free of their R-(&plus;)-isomers, and to pharmaceutical compositions comprising the S(&minus;)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof. These compounds and compositions can be used to systemically and topically treat bacterial Gram-positive, Gram-negative and anaerobic infections, specially resistant Gram-positive organism infections, Gram-negative organism infections, mycobacterial infections and emerging nosocomial pathogen infections, while avoiding toxic effects associated with the administration of the racemic mixture of RS-(&plusmn;)-benzoquinolizine carboxylic acid. The compounds and compositions of this invention can also be used to treat diseases and disorders caused by Gram-positive, Gram-negative and anaerobic bacteria, and diseases and disorders caused by resistant Gram-positive organisms, Gram-negative organisms, mycobacteria and nosocomial pathogens.

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Maharashtra State, India

Nitin Shetty