Fresenius Kabi Ipsum S.r.l.

The Florida State University Research Foundation, Inc.

University of Delhi

Nitin Kumar

Walter Cabri

Saswata Lahiri

Jacopo Zanon

Govind Singh

Antonio Ricci

Shivaji Haribhau Shelke

Madan Singh

Binghe Wang

Sunny Manohar

Nanting Ni

Diwan S Rawat

Xiaochuan Yang

Guojing Sun

Tapanjyoti Biswal

Shridhar Reddy

The present application provides an improved process for the preparation of sugammadex by reacting a salt of 3-mercapto propionic acid with 6-per-deoxy-6-per-halo-&#x3b3;-cyclodextrin in a suitable organic solvent. This application also provides crystalline form of a salt of 3-mercapto propionic acid, preferably di sodium salt of 3-mercapto propionic acid and its use for the preparation of sugammadex, whereas formula (I) shows the sodium salt of sugammadex.

Process for the preparation of sugammadex

The present application provides crystalline forms of 6-per-deoxy-6-per-chloro-&#x3b3;-cyclodextrin, and polymorphs thereof. The present application also provides methods for preparing said polymorphs by dissolving 6-per-deoxy-6-per-chloro-&#x3b3;-cyclodextrin in dimethylformamide and using an anti-solvent of a water/alcohol mixture.

Crystalline forms of per-chloro-&#x3b3;-cyclodextrines

Compounds having Formula I or II, and methods of making and using thereof, are described herein: 

Curcumin analogs and methods of making and using thereof

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Delhi, India

Nitin Kumar