Mylan Laboratories Limited

Torrent Pharmaceuticals Limited

Nitin Ashok Shimpi

Sunil Sadanand Nadkarni

Arabinda Sahu

Ramakoteswara Rao Jetti

Aggi Ramireddy Bommareddy

Neelima Bhagavatula

Siva Koteswara Rao Prathi

Siva Rama Prasad Vellenki

Anil Ponnuru

Lakshmana Rao Ampolu

Satish Babu Kothari

Vellanki Sivaram Prasad

Anil Kumar Ponnuru

Srinivasa Rao Avv

Mahendra Gordhanbhai Lakkad

Siva Rama Vellenki

The amorphous form of trisodium sacubitril valsartan and methods for the preparation thereof are disclosed herein.

Amorphous trisodium sacubitril valsartan and a process for the preparation thereof

The present invention relates to a novel process for the preparation of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol of formula I by reacting a compound of formula VII with the compound of formula R2-OH in the presence of haloginating agent to obtain a compound of formula VI and treating a compound of formula VI with dehaloginating agent to obtain a compound of formula V by reducing a compound of formula V, followed by cylization to obtain compound of formula IV and separating the enantiomer and diastereomers from compound of formula IV to yield a compound of formula I. Compound of formula I is useful as an intermediate in the preparation of protease inhibitors, in particular broad spectrum HIV protease inhibitors, the present invention also relates to process for the preparation of Darunavir from (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol.

Process for the preparation of (3R, 3aS, 6aR)-hexahydrofuro [2, 3-b] furan-3-ol

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Telangana, India

Nitin Ashok Shimpi