Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Teva Pharmaceutical Industries Limited

Other

Ben-gurion University of the Negev Research and Development Authority

Makhteshim Chemical Works Ltd.

Lycored Natural Products Industries Ltd.

Nutralease Ltd.

Makhteshim Agan of North America Ltd.

Nissim Garti

Abraham Aserin

Sharon Garti Levi

Rotem Edri

Yana Berkovich

Judith Aronhime

Ben-Zion Dolitzky

Claude Singer

Morris Zelkha

Neomi Gershon

Anita Liebermann

Tanya Sedlov

Dov Hartal

Asher Porath

Sara Sarig

Zecharia Madar

Yigal Raveh

Francoise Tibika

Margaret E Ginzburg

Zvi Goldman

Ben Z Ginzburg

Joel Sasson

Moshe R Bloch

Arnon Shani

Mordechai Ben-Yehuda

Boaz Sternheim

Alexey Kamishny

Helga F Milhofer

My Perlstein

Idit Amar

Aviram Spernath

Dima Libster

Idit Amar-Yuli

Tehila Mishraki

Liron Bitan-Chervkovsky

Chava Pemberton

Roy Hoffman

Cannabinoid-loaded formulations are characterized by including 0.5 wt. % to 20 wt. % medium chain triglycerides, one or more hydrophilic surfactants, one or more co-surfactants and 0.1 wt. % or more of at least one cannabinoid. The formulations are in microemulsion form, and are fully dilutable by an aqueous diluent.

Dilutable formulations of cannabinoids and processes for their preparation

Provided are cannabinoid-loaded, dilutable microemulsion formulations with low oil content including oleic acid and linoleic acid.

Provided are methods for selective extraction of cannabinoids, for example cannabidiol (CBD), from a plant source, by using tailored extraction media.

Method for selective extraction of cannabinoids from a plant source

Provided is a process for extraction of a lipophilic agent from a plant source, the process including: mixing a first quantity of a plant source, the plant source being containing the lipophilic agent and a first quantity of an extraction medium to obtain a first mixture, the extraction medium being in the form of a microemulsion and comprising at least one oil, at least one hydrophilic surfactant, at least one co-surfactant and optionally at least one co-solvent; homogenizing the first mixture under conditions maintaining the microemulsion structure; and separating the homogenized mixture into a biomass slurry and an agent-loaded medium to obtain the agent-loaded medium in a microemulsion form.

Method for extraction of an agent from a plant source

Provided is a novel dilutable delivery systems and propofol microemulsions suitable for intravenous delivery of propofol.

Delivery systems for propofol

The present invention discloses the use of a lycopene coated with a water non-soluble thin film comprising amphiphilic protein polymer for coloring with red color, foods, pharmaceuticals or cosmetics having fat and/or oil contents higher than 5%. The invention further discloses a process for the preparation of stable lycopene formulation comprising (a) treating an isolated protein to form a protein in a molecular form; (b) dispersing lycopene in an aqueous solution comprising an isolated protein in a molecular form; (c) grinding said dispersion to form lycopene particle size of 1 to 10 &#x3bc;m forming an homogenized mixture comprising fine particles; and optionally (d) drying the homogenized mixture.

Carotenoid formulation

Reverse hexagonal mesophase (H) liquid crystals provide multi-component hexagonal systems for use in solubilizing and/or protecting from degradation one or more bio-macromolecule and/or active material, and relates to therapeutic and non-therapeutic applications, such as an oral delivery system, where the mesophase is adapted for oral administration. The present invention provides the formation of mesophase systems of ternary glycerol monooleate (GMO)/water combinations which comprise at least one triglyceride or an equivalent thereof. At least one biomacromolecule or drug is incorporated in the mesophase of a pharmaceutical composition or oral delivery system.

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Provided are homogeneous liquid systems substantiallyH-NMR inactive and/or devoid of protons and are capable of enhancing the diffusion separation of a mixture, the system is substantially devoid of at least one NMR active nucleus present in the mixture. Further provided are methods of using the homogeneous liquid systems for enhancing the diffusion separation of a mixture and/or generating a diffusion ordered spectrum of a mixture and/or minimizing the peak width in a liquid state diffusion ordered spectrum of a mixture.

Liquid compositions and uses thereof for generating diffusion ordered NMR spectra of mixtures

The present invention relates to lamotrigine, a useful agent for anti-epilepsia. New crystal forms of lamotrigine containing molecules of the solvent in stoichiometric ratios are disclosed. The present invention also provides processes for preparing the new crystal forms of lamotrigine.

Crystal forms of lamotrigine and processes for their preparations

The present invention provides for new crystal forms of oxcarbazepine, more particularly oxcarbazepine Forms B, C, D and E. The present invention further provides processes for preparation of these forms. Form B is prepared by evaporating the solvents from a solution of oxcarbazepine in toluene and dichloromethane. Form B is also obtained by immediately cooling the solution of oxcarbazepine and toluene. Cooling the same solution at a slower rate, but still fairly rapidly, results in oxcarbazepine Form C. Cooling the same solution at even a slower rate results in another Form, oxcarbazepine Form D. Oxcarbazepine Form E, a solvate of chloroform, is obtained by precipitating a solution of oxcarbazepine and chloroform. The present invention also provides processes for converting one of the newly discovered crystal forms of oxcarbazepine into another crystal form, including Form A, which is in the prior art. These conversions may occur by storage at ambient temperature, by heating one particular Form or treatment with a protic solvent.

Crystal forms of oxcarbazepine and processes for their preparation

The present invention relates to nano-sized self-assembled structured concentrates and their use as effective suitable carriers for transferring active components into the human body. The nano-sized self-assembled concentrates are composed of an aqueous phase, an oil phase, a surfactant a co-solvent and co-surfactant. The formed nano-sized self-assembled structured concentrates may be in the form of an aqueous continuous phase, an oil continuous phase or a bicontinuous phase, and may thus be diluted to any desired extent in either oil or water maintaining their structure and the active material comprised within the nano-sized self-assembled structured concentrates.

Nano-sized self-assembled liquid dilutable vehicles

The present invention relates to a method for the production of particles of nano-materials being transition metals and alloys; metal oxides; and ceramic compositions having a small nanosize, i.e. about 1-6 nm. The method comprises a synthesis in the solutions of complex liquids from suitable precursors, which precursors are selected from suitable surfactants and alkoxides, by a suitable chemical reaction under mild conditions; and preparing from said materials fine colloids dispersed in various polymer solutions. The water in the solution is preferably non freezing water, the mild conditions are atmospheric pressure and a temperature range of room temperature to 70&deg; C., and the reaction condition is selected among a hydrolysis, reduction and exchange process.

Methods for the preparation of nanosized material particles

The invention provides a method of preparing new crystal forms of aspartame utilizing microemulsions comprising: (a) introducing aspartame into a microemulsion formed from an oil phase, an aqueous phase and at least one emulsifier, (b) destabilizing the microemulsion to effect recrystallization of aspartame; (c) separating solid phase crystals from the liquid phase in which they are contained; and (d) cleaning the crystals to remove traces of the oil phase and surfactant.

Aspartame crystals and process for the preparation thereof

Galactomannan products and compositions containing the same

Growing community of inventors

Ramat Hasharon, Israel

Nissim Garti