Harvard College

Dana-farber-cancer Institute Inc.

Life Technologies Corporation

Arizona State University

Arizona Board of Regents, a Body Corporate

Niroshan Ramachandran

Joshua LaBaer

Karen Anderson

Garrick Wallstrom

Sahar Sibani

Chee Kiong Lim

Hon Siu Shin

Chee Wee Ching

Way Xuang Lee

David Bourdon

Chin Yong Koo

Lihao Meng

Suzy Van Le

Manuel Fuentes Garcia

Karen Sue Anderson

The present invention provides reagents and methods for breast cancer detection.

Biomarkers for the early detection of breast cancer

A thermal block assembly including a sample block and two or more thermoelectric devices, is disclosed. The sample block has a top surface configured to receive a plurality of reaction vessels and an opposing bottom surface. The thermoelectric devices are operably coupled to the sample block, wherein each thermoelectric device includes a housing for a thermal sensor and a thermal control interface with a controller. Each thermoelectric device is further configured to operate independently from each other to provide a substantially uniform temperature profile throughout the sample block.

Apparatuses, systems and methods for providing thermocycler thermal uniformity

The disclosure provides SLE biomarkers. The disclosure further provides kits and methods of diagnosing, prognosing, and stratifying subjects with the disease by utilizing SLE biomarkers.

Biomarkers for systemic lupus erythematosus

The disclosure features methods that include: providing a substrate that includes (i) a nucleic acid (e.g., DNA or RNA) encoding a hybrid amino acid sequence including a test amino acid sequence and an affinity tag, and (ii) a binding agent that recognizes the affinity tag; contacting the substrate with a translation effector to thereby translate the hybrid amino acid sequence; maintaining the substrate under conditions permissive for the hybrid amino acid sequence to bind the binding agent; and removing the nucleic acid from the substrate. In one embodiment, the substrate includes a plurality of positionally-distinguishable addresses, for example, each include a different nucleic acid. The addresses can be located a regularly or irregularly spaced locations.

Evaluating proteins

Growing community of inventors

San Marcos, CA, United States of America

Niroshan Ramachandran