The University of Sydney

Nirmesh Jain

Brian Stanley Hawkett

Thi Thuy Binh Pham

Trevor William Hambley

Nicole Sarah Bryce

Yanjun Wang

Gregory Goodman Warr

The present invention relates generally to a method of treating a neoplastic condition and to agents useful for same. More particularly, the present invention is directed to a method of facilitating the treatment of a solid tumor in a localized manner via the co-administration of particulate material and a cellular toxin. The method of the present invention is useful in a range of therapeutic treatments including the treatment of primary and metastatic tumors.

Method for the treatment of a solid tumour

The present invention relates to polymer microgel beads having a polymeric matrix with nanomagnetic particles dispersed substantially uniformly therethrough, wherein a steric stabilizer is associated with the particles, the steric stabilizer being a polymeric material that (i) forms at least part of the polymeric matrix of the beads, and (ii) comprises a steric stabilizing polymeric segment and an anchoring polymeric segment, wherein the steric stabilizing polymeric segment is different from the anchoring polymeric segment, and wherein the anchoring polymeric segment has an affinity toward the surface of the nanomagnetic particles and secures the stabilizer to the particles.

Polymer microgel beads and preparative method thereof

The present invention relates to polymer microgel beads having a polymeric matrix with nanomagnetic particles dispersed substantially uniformly therethrough, wherein a steric stabiliser is associated with the particles, the steric stabiliser being a polymeric material that (i) does not form part of the polymeric matrix of the beads, and (ii) comprises a steric stabilising polymeric segment and an anchoring polymeric segment, wherein the steric stabilising polymeric segment is different from the anchoring polymeric segment, and wherein the anchoring polymeric segment has an affinity toward the surface of the nanomagnetic particles and secures the stabiliser to the particles.

Polymer microgel beads

The present invention relates to a composition suitable for administration to a subject, the composition comprising pharmacologically acceptable particulate material dispersed throughout a pharmacologically acceptable liquid carrier, the particulate material being maintained in the dispersed state by a steric stabilizer, wherein the steric stabilizer is a polymeric material comprising a steric stabilizing polymeric segment and an anchoring polymeric segment, one or both of which are derived from one or more ethylenically unsaturated monomers that have been polymerized by a living polymerization technique, wherein the steric stabilizing polymeric segment is different from the anchoring polymeric segment, and wherein the anchoring polymeric segment has an affinity toward the surface of the particulate material and secures the stabilizer to the particulate material.

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Paramatta, Australia

Nirmesh Jain