Nostrum Energy Pte. Ltd.

Nostrum Pharmaceuticals, Inc.

Pharmasolutions, Inc.

Norstrum Pharmaceuticals, Inc.

Nostrum Energy Pte, Otd.

Tris Pharma, Inc.

Nirmal Mulye

Osanan L Barros Neto

Shrikrishna Kashinath Sane

Vijay Shukla

Kavita Inamdar

Frank S Loscrudato

William R Atkinson

Vinayak Manmadkar

Frank L Loscrudato

Osanan L Barrosneto

An injector nozzle used with an internal combustion engine for shaping a fluid flow is provided. The nozzle has a body and an orifice plate provided at an outlet of the body. The body and the plate extend symmetrically with respect to a central axis. The plate has an interior surface and an opposite exterior surface, which are substantially parallel to each other to define a thickness of the plate. The plate has fluid passageways each having an orifice on the exterior surface. The fluid flow diverges through the fluid passageways to create stream jets. The imaginary extensions the passageways converge to create a focal point and an included angle associated with the focal point.

Fluid injector orifice plate for colliding fluid jets

An internal combustion engine is equipped with a water injector for cooling the internal combustion engine by a spray of atomized water into the intake track or combustion chamber prior to ignition. The atomized water spray may be in the intake manifold or directly in the cylinder. The water is injected at a volume of between a ratio of about 95% fuel to about 5% water and about 50% fuel and about 50% water. The temperature of the internal combustion engine is maintained at between about 95&#xb0; C. and about 200&#xb0; C. during operation.

Internally cooled internal combustion engine and method thereof

A liquid injector for injection of liquids into internal combustion engines is provided. The injectors have a plurality of jets aimed at a common collision point, where at least two jet streams collide to create a finely atomized liquid due to kinetic energy dissipated by the impact of the liquid streams. The angle formed by the jets, the pressure applied and the distance at which the jets collide is such that the loss of forward momentum is greater than the energy required to create particles smaller than 5 microns. Liquids injected may include gasoline, diesel-type fuels, or water. The injectors may be employed for port injection or direct injection.

Liquid injector atomizer with colliding jets

An internally cooled internal combustion piston engine and method of operating a piston engine is provided, with the combination of liquid water injection, higher compression ratios than conventional engines, and leaner air fuel mixtures than conventional engines. The effective compression ratio of the engines herein is greater than 13:1. The engines may employ gasoline or natural gas and use spark ignition, or the engines may employ a diesel-type fuel and use compression ignition. The liquid water injection provides internal cooling, reducing or eliminating the heat rejection to the radiator, reduces engine knock, and reduces NOx emissions. The method of engine operation using internal cooling with liquid water injection, high compression ratio and lean air fuel mixture allow for more complete and efficient combustion and therefore better thermal efficiency as compared to conventional engines.

Internally cooled high compression lean-burning internal combustion engine

A liquid injector atomizer for direct injection in to the cylinder of an internal combustion engine is provided, with a supply of pressurized liquid a supply of pressurized gas, a body, and a nozzle with two or more orifices each for the liquid and the gas. Each orifice directs a jet of metered pressurized liquid or gas out of the injector body. At least two of the liquid jets are aimed at one or more collision points, where at least two gas jet streams collide at a same collision point or another collision point, thereby creating a finely atomized liquid.

Gas-assisted fluid atomizing injector

A hydrokinetic energy conversion system (HKECS) is provided, comprising design configurations suitable for efficient production of tidal or river in-stream kinetic energy into useful mechanical energy for tasks such as generating electricity or water pumping. The apparatus includes a set of blades with an airfoil cross sectional contour moving on a horizontal or vertical closed loop track, whereby the blades are propelled through the water by a net tangential lift force, rather than drag, to effectively convert the kinetic energy of flowing water to useful power.

Hydrokinetic energy conversion system

The present invention is directed to a process of preparing beads coated with a water soluble drug for incorporation into a pharmaceutical composition comprising: (a) preparing a supersaturated drug solution containing a desired amount of drug, which is completely saturated at a first temperature but which is supersaturated at a second temperature which is below the first temperature; and (b) coating inert beads with the drug solution, said drug solution being maintained at or below the first temperature but above the second temperature, and said beads maintained at a second temperature, wherein the second temperature is less than the first temperature and wherein the solution containing the drug is supersaturated at the second temperature, as well as to the pharmaceutical compositions containing same.

Pharmaceutical composition containing water soluble drug

The present invention is directed to a sustained release pharmaceutical composition in oral dosage form consisting essentially of a pharmaceutically effective amount of a medicament and a hydrophobic material in the absence of a lactose or hydrophobic carbohydrate polymer, said medicament being present in an amount greater than about 25% of the pharmaceutical composition and having a water solubility greater than about 1 gram per 10 mL of water at 25&#xb0; C., said hydrophobic material having a melting point ranging from at least about 40&#xb0; C. to about 100&#xb0; C. at 1 atm pressure, and being present in an amount ranging from about 3% to about 20% by weight of the pharmaceutical composition and in an amount less than the of the medicament, and said hydrophobic material not being present in coating of said pharmaceutical composition; said pharmaceutical composition being prepared by direct compression in the absence of or melting the hydrophobic material or the use of high shear mixer. The present invention is also directed to a method of preparing said pharmaceutical composition.

Control release formulation containing a hydrophobic material as the sustained release agent

The present invention is directed to a controlled release formulation in tablet form comprising a pharmaceutically effective amount of an erythromycin derivative and a lubricating effective amount of a lubricant in the absence of material selected from the group consisting of alginic acid or salts thereof or hydrophilic sustained release polymers in amounts effective to retard the release of the erythromycin derivatives in the pharmaceutical composition. It is also directed to a method for facilitating the release of erythromycin derivative from a pharmaceutical composition comprising a therapeutically effective amount of a lubricating effective amount of a lubricant said method comprising adding to said composition an release promoter in tablet disintegrating effective amounts to facilitate the release of the erythromycin derivative from the tablet.

Controlled release formulation of erythromycin derivatives

The present invention is directed to the process of preparing a sustained release niacin tablet and the product prepared therefrom.

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Kendall Park, NJ, United States of America

Nirmal Mulye