Oregon State University

Niran Roongsawang

Taifo Mahmud

Takuya Ito

Norifumi Shirasaka

Patricia M Flatt

This disclosure describes the molecular cloning of a pactamycin biosynthetic gene cluster fromATCC 27456, characterization of individual genes in the gene cluster and the proteins encoded thereby as well as uses thereof. The pactamycin gene cluster is located within an 86.35 kilobases genetic locus and includes 53 open reading frames, 26 of which are considered to be the core cluster directly involved in the biosynthesis of pactamycin. The present disclosure also relates to the use of the pactamycin biosynthetic genes located within the identified gene cluster for drug design and development purposes, including the development of pactamycin analogs that are more efficacious and less toxic. Also provided are drugs and antibiotics so produced, as well as methods of their use.

Growing community of inventors

Corvallis, OR, United States of America

Niran Roongsawang