Perrigo Israel Pharmaceuticals Ltd.

Sol-Gel Technologies Ltd.

Deeay Technologies Ltd.

Nir Avram

Eilon Asculai

Marina Shevachman

Batella Binyaminovich

Chaim Aschkenasy

Amira Ze' Evi

Amira Ze'Evi

Batella Benyaminovich

Topical vaginal compositions are disclosed herein which include silica microspheres and an active ingredient in the amount of 0.001 to 15.0% w/w selected from estradiol, metronidazole, clindamycin, butoconazole, and combinations thereof. The topical compositions provide sustained release of the active ingredient so as to reduce skin irritation.

Pharmaceutical compositions comprising silica microspheres

A topical composition which includes a silica microspheres and an active ingredient in the amount of 0.01 to 15.0% w/w wherein the active ingredient is selected from adapalene, an antibiotic, tazarotene, tretinoin, a retinoid, or any combination thereof. The topical composition may also include benzoyl peroxide as an active ingredient. The topical compositions provide sustained release of the active ingredient so as to reduce skin irritation.

The present invention relates to a topical composition which includes a bioactive drug formulated with silica in the form of microspheres, or drugs in a combination with the silica microspheres in an oily suspension, gel or emulsion. The topical compositions of the invention provide sustained release of a bioactive drug so as to reduce skin irritation.

A dishwashing method is dislosed wherein two detergent compositions, one being alkalinic and the other acidic are applied in sequence onto the dishes. The liquid compositions are applied onto the dishes directly without or with only a moderate dilution such that once applied onto the dishes they input respective alkalinic and acid pH's on the surface of the dishes.

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Meitar, Israel

Nir Avram