Immudyne, Inc.

Vide Pharmaceuticals

Rush-presbyterian-st. Luke's Medical Center

Nino Sorgente

Charles Bakhit

Klaus E Kuettner

Arun K Bahl

Harald L Guenther

Robert M Nakamura

Hannelore E Guenther

Reuben Eisenstein

The invention provides methods of using beta glucans to treat conditions associated with bone loss or low bone density as well as methods for promoting bone growth in situations where enhanced bone growth is desirable. In the invention methods beta glucans are administered so as to enhance the development of osteoblasts and the inhibition of the development and recruitment of osteoclasts. The inhibition of the recruitment and development of osteoclasts, coupled with the enhancement of osteoblast maturation by beta glucans leads to decreased bone resorption and increased bone formation, making beta glucans ideal agents for the treatment of osteoporosis and other bone resorption diseases.

Use of beta glucans for the treatment of osteoporosis and other diseases of bone resorption

The invention describes compositions and methods for treatment of rheumatoid arthritis and osteoarthritis. The compositions comprise insoluble, native collagen Type II in a particular form in combinations with other active agents, including glucosamine, chondroitin, ascorbate, boron and magnesium. Also described are methods for producing particulated insoluble native collagen Type II.

Methods for treating arthritis using collagen type II, glucosamine

ATP-sensitive K.sup.+ channel modulating compounds are incorporated into ophthalmically acceptable carriers for administration to the eye in order to affect intraocular pressure. Such formulations including compounds which inhibit the channel are particularly suitable for treating glaucoma and other disorders related to elevated intraocular pressure. Such formulation which potentiates the channel are particularly suitable for treating hypotonia and other depressed intraocular pressure conditions.

Methods and compositions for ATP-sensitive K.sup.+ channel inhibition

A composition of matter having activity as an inhibitor of cell proliferation is obtained by aqueous extraction of tissue having a high content of collagen and/or proteoglycans.

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Los Angeles, CA, United States of America

Nino Sorgente