Chengdu Easton Biopharmaceuticals Co., Ltd

Chengdu Easton Pharmaceutical Co., Ltd.

The Second Research Institute of Caac

Zhejiang Yatai Pharmaceutical Co., Ltd.

Ning Zhou

Jian Ming Liu

Ying Wang

Guodong Cen

Jian Liu

Long Huang

Yongzhe Xiang

Jibing Zhang

Hui Qiao

Hai Xiang

Wenwu Wang

Hua Liu

Zuxi Xia

Tai Zeng

The present invention relates to the field of pharmaceutical chemistry, specifically to a class of compounds containing lactam and derivative thereof, and especially to a pyridine derivative as shown in general formula (I), preparation method and the use thereof as a Factor Xa inhibitor. The present invention further relates to the medical use of the compound and derivative thereof in preparation of anticoagulant drugs, particularly to the use in preparation of drugs for preventing or treating thrombosis or embolism. 

Pyridine derivative and medical use thereof

The present invention discloses a xanthine derivative having the structure of the following general formula (I) or a pharmaceutically acceptable salt thereof; further discloses a preparation method for the xanthine derivative or a pharmaceutically acceptable salt thereof; and further discloses the use of the xanthine derivative or a pharmaceutically acceptable salt thereof. Through experiments of DPP-IV activity inhibition experiments in vitro, impact on glucose tolerance in normal mice and impact on blood glucose in spontaneous diabetic mice, it proves that the compounds and pharmaceutically acceptable salts thereof show good DPP-IV inhibition activity, can be applied to prepare medicines for treating dipeptidyl peptidase IV-related diseases, and more particularly, can be applied to the use of medicines for treating type II diabetes or diseases of abnormal glucose tolerance. 

Xanthine derivative

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Chengdu, China

Ning Zhou