Caliper Life Sciences, Inc.

Xenogen Corporation

Ning Zhang

Rajendra Singh

Daniel Ansaldi

Jae Beom Kim

Zhenjun Diwu

Pamela R Contag

Anthony Purchio

Kevin P Francis

Stephen Oldfield

Compositions and methods are described for normalizing a bioluminescent signal in a live animal.

Compositions and methods for in vivo evaluation of bioluminescence

Compositions and methods are described for detecting enzyme activity in a live organism (e.g., animal) are provided.

In vivo imaging of enzymatic activity

Multivalent fluorescent probes and methods of using these multivalent fluorescent probes for in vitro and in vivo imaging are described.

Multivalent fluorescent probes

The present invention relates to panels of reporter expression cassettes and the generation of transgenic non-human animals, wherein said reporter expression cassettes have selected control elements operable linked to reporter genes. The invention includes methods of use thereof for the identification and characterization of the effects of compounds administered to the live transgenic non-human animals.

Non-invasive evaluation of physiological response in a transgenic mouse

The present invention relates to novel promoters, including transcription regulator regions, for the mouse VEGFR-2 receptor, isolated polynucleotides comprising such promoters, nucleic acid constructs comprising such promoters operatively linked to genes encoding a gene product, such as, a reporter, a protein, polypeptide, hormone, ribozyme, or antisense RNA, recombinant cells comprising such nucleic acid constructs, screening for therapeutic drugs using such cells (e.g., screening for compounds that modulate VEGFR-2-mediated angiogenesis), and endothelial tissue-specific gene expression using these novel promoter sequences.

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Alameda, CA, United States of America

Ning Zhang