Harvard College

Children's Medical Center Corporation

University of Paris

Ning Wang

Jeffrey J Fredberg

Donald Elliot Ingber

James P Butler

Georgia Barlovatz-Meimon

The present invention is directed to a method for regulating formation of a complex of a plasminogen activator, its receptor and one of its inhibitors. More specifically, this method involves contacting a target cell having a plasminogen activator receptor with a compound which interacts with a component of the complex such that a change in target cell cytoskeletal stiffness results.

Method for regulating formation of a complex of plasminogen activator,

Mechanical stresses and deformations are applied directly to cell surface receptors or molecules and measured using a system including a magnetic twisting device in combination with ferromagnetic microbeads coated with ligands for integrins or any other surface receptors. The system can be used diagnostically to characterize cells and molecules and to determine the effect of transformation and compounds, including drugs, on the cells and molecules. The system can also be used to induce cells to grow or alter production of molecules by the cells.

Method and system for measurement of mechanical properties of molecules

Growing community of inventors

Wuhan, China

Ning Wang