Other

Shanghai Jin Feng Yu Glove Co., Ltd.

Chinese Academy of Sciences

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Jiangsu Kanion Pharmaceutical Co., Ltd.

Fujian Akeylink Biotechnology Co., Ltd.

Dynamiker Biotechnology (tianjin) Co., Ltd.

Fuijan Cosunter Pharmaceutical Co. Ltd.

Shenzhen Salubris Pharm Co Ltd.

Guangxi Xi Nuo Sheng Glove Co., Ltd.

Shanghai Bingxin Trading Co., Ltd.

Fujian Cosunter Pharmaceutical Co., Ltd.

Ning Li

Jian Li

Chengde Wu

Tao Yu

Shuhui Chen

Jiahu Wu

Wenlan Cai

Zeqi Zhou

Wei Lu

Peng Li

Zhibin Li

Yan Su

Jie Peng

Haiying He

Yong Wang

Wang Shen

Zheng Wang

Bo Zhang

Feng Guo

Wei Xiao

Jie Gandalf Yan

Changjun Wang

Zhifeng Li

Bailing Yang

Xiaoshuang Chen

Zongbin Li

Wenjie Xu

Chunlong Liu

Lingwei Kong

Zhou Zhang

Shaowei Wang

Wen-Lan Cai

Pingping Chen

Haisheng Mo

Shengbin Zhang

Yusheng Fu

Qing Feng Li

Dongdong Shi

Peipei Jiang

Zhemin Rong

Shuanzhu Zhai

Provided are crystal forms A, B, C and D of a compound of formula (I), and application of the crystal forms in the preparation of drugs for treating ASK1-related diseases.

Crystal form as ASK1 inhibitor and preparation method and application thereof

Floor lamp

Disclosed in the present invention are a compound as shown in formula (II), a tautomer or a pharmaceutically acceptable salt thereof, and also disclosed is the use thereof in preparing a drug for treating an ASK1-associated disease. 

Pyridine derivative as ASK1 inhibitor and preparation method and use thereof

A glove has a glove core and a glove component. The glove core has a palm portion, a dorsum portion, a side portion of hand and a finger portion; the palm portion and the finger portion are connected to each other via a connection point, the finger piece portion has a first and second bonding portions with a distance therebetween, the finger piece portion is bound to the finger portion via the first bonding portion, and the finger piece portion is bound to the palm portion via the second bonding portion. The connection point, the first bonding portion and the second bonding portion are formed to have a virtual triangle, thus the finger portion and the palm portion have an angle being less than 180 degrees, and that is, the finger portion bends forward the palm portion to make the glove comply with the ergonomic principle.

Glove

A glove structure of the present invention has a glove palm, a glove back and an edging. The edging is a bent sheet and has an upper side edge and a lower side edge, wherein the lower and upper side edges are respectively adhered to the glove palm and the glove back via joining regions, and the lower and upper side edges bend toward the glove palm. Thus, the whole glove structure bends along a direction being from the glove back to the glove back to make the glove structure be a ergonomics structure which the fingers bend toward the glove palm when the human hand is under a working state or a general state without force.

Glove structure

The present disclosure relates to a compound as shown in formula (II), a tautomer or a pharmaceutically acceptable salt thereof, and disclosed is the use thereof in preparing a drug for treating an ASK1-associated disease. 

ASK1 inhibitor and preparation method and use thereof

The present invention discloses a preparation method ofcapsular polysaccharide GXM as well as a GXM antigen immunoassay kit and an application thereof. The preparation method of thecapsular polysaccharide GXM effectively avoids the use of a toxic chemical reagent, ensures safety of operators, and also avoids environmental pollution, has high specificity, and can prepare a high-puritycapsular polysaccharide while simplifying a preparation process. The GXM antigen immunoassay kit adopts a competition method, has good sensitivity, specificity, repeatability and stability, has high recovery rate of a target compound and may provide more accurate and reliable inspection results. The kit is simple and feasible in use and operation, rapid and sensitive in detection and low in price and provides an effective tool for clinical detection of GXM.

Preparation method of Cryptococcus neoformans capsular polysaccharide GXM as well as GXM antigen immunoassay kit and application thereof

One aspect of the invention relates to a series of new PCSK9 inhibitor compounds comprising piperidine ring structures, including compounds of formula (I) and/or pharmaceutically acceptable salts thereof. Another aspect of the invention relates to methods of treating PCSK9 receptor related diseases comprising administration of one or more compounds of formula (I) or a pharmaceutically acceptable salt thereof. 

Piperidine compounds as PCSK9 inhibitors

Disclosed in the present invention are a crystalline Form of pyrido[1,2-a]pyrimidone analog, a preparation method therefor and an intermediate thereof. 

Pyrido[1,2-A]pyrimidone analog, crystal form thereof, intermediate thereof and preparation method therefor

The present invention provides a hybridoma cell under the accession number CGMCC No. 13827. The hybridoma cell is capable of producing a monoclonal antibody againstgalactomannan antigen and a kit is prepared using the same. The kit provided by the present invention can specifically bind to the GM antigen, has both sensitivity and specificity of more than 95%, a detection limit of 0.85 ng/mL compared to 1 ng/mL of the existing product, and high compliance rate between the detection result and the reference reagent, and can provide more accurate and reliable detection results, so that IA can be detected early in the course of the disease and the patients can receive treatment in timely and effective manner, thereby improving the survival rate of patients. Moreover, the kit has simple and convenient operation, rapid and sensitive detection, which provides an effective tool for the quantitative detection ofGM antigen.

GM hybridoma cell, monoclonal antibody, kit and preparation method and use thereof

A glove includes a glove core and a glove component. The glove core includes a palm portion, a dorsum portion and a side portion of hand. A side of the glove component is adhered on a surface of the glove core, and the glove component covers a part of the palm portion and a part of the dorsum portion of the glove core, a part of the palm portion and a part of the side portion of hand of the glove core, or a part of the dorsum portion and a part of the side portion of hand of the glove core, such that the glove core can be combined with the enhanced glove component, forming a structure which is simple in structure and can be formed easily. Furthermore, the robustness of the glove can be improved significantly to be provided with practicability and progressiveness.

Disclosed is a novel anti-enterovirus 71 (EV71) 1,2,5-thiadiazolidine-1,1-dioxide derivative or a pharmaceutically acceptable salt thereof, and specifically, a compound represented by formula (II) or a pharmaceutically acceptable salt thereof. 

Anti-enterovirus 71 thiadiazolidine derivative

Taught herein is an integragted narrow bandpass filter array and a method of its fabrication. The filter array is a Fabry-Perot type of filter array, wherein the pass band changes with the thickness of the spacer layer. The integrated filter array comprises a substrate, a lower mirror stack, a spacer array, and an upper mirror stack. The spacer array is an array of varied thicknesses formed using a combinatorial deposition technique. The spacer array is used to control the pass band of each mini-size narrow bandpass filter and realizes the integration of narrow bandpass filters with different pass bands on a single substrate. The merit of this technique lies in its fabrication efficiency and finished product rate which are much higher than for conventional methods. The filter array is completely matched with detector arrays and functional in most of the important optical ranges.

Integrated narrow bandpass filter array and a method for fabrication thereof

Growing community of inventors

Shanghai, China

Ning Li