Basf Se Corporation

Nina Challand

Johann-Peter Melder

Michael Rack

Joachim Rheinheimer

Roman Dostalek

Ansgar Gereon Altenhoff

Joachim Schmidt-Leithoff

Thomas Zierke

Christof Wilhelm Wigbers

Udo Rheude

Bernd Stein

Sebastian Peer Smidt

Roland Bou Chedid

Ulrich Abel

Michael Jödecke

Kathrin Wissel-Stoll

Arnulf Tröscher

Franziska Troescher

Johanna Troescher

Process for preparing piperazine of the formula I by reacting diethanolamine (DEOA) of the formula II with ammonia in the presence of hydrogen and a supported, metal-containing catalyst has been found, wherein the catalytically active mass of the catalyst, prior to its reduction with hydrogen, comprises oxygen-containing compounds of aluminum, copper, nickel and cobalt and in the range from 0.2 to 5.0% by weight of oxygen-containing compounds of tin, calculated as SnO, and the reaction is carried out in the liquid phase at an absolute pressure in the range from 160 to 220 bar, a temperature in the range from 180 to 220&#xb0; C., using ammonia in a molar ratio to DEOA used of from 5 to 25 and in the presence of 0.2 to 9.0% by weight of hydrogen, based on the total amount of DEOA used and ammonia.

Process for preparing piperazine

Process for the preparation of aromatic and heteroaromatic carboxylic acids, carboxylic acid esters and carboxamides by the reaction of aromatic or heteroaromatic halides R&#x2014;X, in which n=integer from 1 to 6, R=substituted or unsubstituted and aromatic or heteroaromatic radical and X=chlorine, bromine or iodine atom, with carbon monoxide and water, ammonia, alcohols or amines in the presence of bases and zero-valent or divalent palladium compounds and bidentate diphosphanes or complexes of zero-valent or divalent palladium with bidentate diphosphanes, in which use is made of bidentate diphosphanes(R&#x2014;)(R&#x2014;)P&#x2014;Y&#x2014;P(&#x2014;R)(&#x2014;R)in which Rto R=unsubstituted aryl radicals or aryl radicals substituted with at least one radical exhibiting a positive resonance effect or a positive inductive effect, or unsubstituted or substituted cycloalkyl radicals, and Y=hydrocarbon group with a total of 2 to 20 carbon atoms, in which at least one of the carbon atoms carries only one or no hydrogen atom as substituent; except for the reaction of 4-bromo-3-difluoromethyl-1-methylpyrazole with 2-(3,4,5-trifluorophenyl)aniline and carbon monoxide to give N-[2-(3,4,5-trifluorophenyl)phenyl]-3-difluoromethyl-1-methylpyrazole-4-carboxamide.

Method for producing aromatic and heteroaromatic carboxylic acids, carboxylic acid esters and carboxylic acid amides

Process for preparing 1,4-bishydroxyethylpiperazine (BHEPIP) of the formula I wherein diethanolamine (DEOA) of the formula II is reacted in the liquid phase in a reactor at a temperature in the range from 130 to 300&#xb0; C. in the presence of a copper-comprising, chromium-free heterogeneous catalyst.

Process for preparing 1,4-bishydroxyethylpiperazine

The present invention relates to a process for preparing N-substituted (3-dihalomethylpyrazol-4-yl)carboxamides of the formula (I) in which Ris optionally substituted phenyl or C-C-cycloalkyl, Ris hydrogen or fluorine, or Rtogether with Ris optionally substituted C-C-alkanediyl or C-C-cycloalkanediyl, Ris C-C-alkyl, C-C-alkenyl, C-C-alkynyl or C-C-alkoxy-C-C-alkyl, X is F or Cl and n is 0, 1, 2 or 3; which comprisesA) providing a compound of the formula (II) in which X is F or Cl, Y is Cl or Br and Rhas one of the meanings given above andB) reacting a compound of the formula (II) with carbon monoxide and a compound of the formula (III) in which R, Rand n have one of the meanings given above; in the presence of a palladium catalyst;to intermediates used for the preparation according to the process according to the invention, and also to processes for their preparation.

Method for the production of N-substituted (3-dihalomethyl-1-methylpyrazol-4-yl) carboxamides

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Mannheim, Germany

Nina Challand