Other

University of Toronto

Milica Radisic

Nimalan Thavandiran

Boyang Zhang

Yimu Zhao

Jason Miklas

Sara Vasconcelos

Yun Xiao

Peter Zandstra

The present disclosure provides methods, compositions, and devices for making and using three-dimensional biological tissues that accurately mimic native physiology, architecture, and other properties of native tissues for use in, among other applications, drug testing, tissue repair and/or treatment, and regenerative medicine.

Methods for modeling disease tissue using three-dimensional tissue systems

Compositions and methods for making and using three-dimensional tissue systems

Methods and devices are provided for the formation of cardiac tissue constructs. In some embodiments, methods are provided for forming cardiac tissue constructs that including cardiomyocytes, non-myocytes, and extracellular matrix, and which exhibit properties associated with healthy cardiac tissue. In some embodiments, microfabrication platforms are provided to support the transmission of dynamic electromechanical forces, such that the cardiac microtissue constructs may be formed mimicking the basic microenvironment found in the heart. The microfabrication platform may include retaining features for stabilizing the position of the microtissue construct during its formation, and the microfabrication platform may include a ramped support configured to produce tissue constructs having a ring geometry. In some embodiments, the microfabrication platform may be configured to for the application of point electrical stimulation, and/or to amplify the transduction of force into a visible displacement.

Cardiac tissue constructs and methods of fabrication thereof

Growing community of inventors

Toronto, Canada

Nimalan Thavandiran