Biotage Ab

Personal Chemistry I Uppsala Ab

Nils-Fredrik Kaiser

Mats Larhed

Anders Rudolf Hallberg

Mathias Alterman

Yiqian Wan

Hallberg Anders

Ulf Bremberg

Christina Moberg

The present invention is drawn to a method of performing a one-pot organic reactions including carbon monoxide as reactant, without the use of an external CO gas source, wherein a reaction mixture containing a solid or liquid CO releasing compound, a non-metal substrate and a metal catalyst is exposed to an energy source to release carbon monoxide from the CO releasing compound and wherein carbon atoms of the released carbon monoxide form a bond with the non-metal substrate compound. The present invention is further drawn to a method of preparing chemical libraries and a kit for organic reactions.

Organic reactions with CO generating materials

The present invention is draw to microwave heating of a transition metal-catalysed organic reaction, in which a catalyst complex between a transition metal and an auxiliary ligand or ligands, the ligand being asymmetric or symmetric, monodentate or bidentate, results in highly chemoselective, regioselective, and stereoselective allylic substitution reactions. Molybdenum or palladium complexes form suitable catalytic systems with a plethora of ligands in a variety of solvents for such microwave facilitated nucleophilic substitution reactions.

Microwave facilitated allyllic substitution

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Uppsala, Sweden

Nils-Fredrik Kaiser