Kenova Ab

Aktiebolaget Hassle

Other

Ab Astra

Astra Meditec Ab

Tally Safe Systems Ab

Nils B Nilson

Bengt G Berglund

Ake S Nilsson

Arne T Eek

Kjell I Wellenstam

Nils-Ake W Ternerot

Karl-Erik L Falk

Anders T Kers

Lars-Erik Andersson

Karl-Axel Hook

Dan A Magnusson

Transfer cannula

Drug release valve for a parenteral administration system

The invention relates to an automatic two-chamber injector for mixing and injecting a medical solution. The injector comprises a barrel (11) having a first end with a receiving portion (15) for an injection needle (17), said portion being sealed prior to use, and a second end with a displaceable plunger (27). The barrel (11) comprises two chambers (29, 30) separated by a migrationproof membrane (28), said membrane (28) being adapted to rupture when the plunger (27) is displaced towards the first end of the barrel (11). The invention also related to a method for mixing and injecting a solution by means of an automatic two-chamber injector and to a cartridge for a two-chamber injector.

Automatic two-chamber injector

A seal for container locks and the like comprises two units (1,2,3;8,14,15) which are snapped into each other. The snap action is carried out by means of a plug (14) forming part of one of the units (8,14,15) and which normally closes a cavity (13) containing an indicating means (21). When the parts are separated the plug is drawn out from this position and allows the indicating means to leave said cavity. In one embodiment the plug (14) is hollow and is closed by means of a steel pin (15) which when inserted has put the indicating means under pressure and the plug has blocking vanes (18). In another embodiment the plug is not hollow but has a weak lower portion and supports a resilient blocking ring. A steel pin floats in the cavity and can break the weak wall when an attempt to brake the seal is made.

Seal

A drug release device for inclusion in a parenteral drug delivery system, said device comprising a chamber having an inlet for a liquid administerable to a patient by a parenteral route, a drug dissolution space within said chamber, through which said liquid can be made flow, an outlet for said liquid, and means for receiving and retaining within said drug dissolution space a drug preparation from which a drug is releasable to said liquid during such parenteral delivery, said device characterized in having means for providing the same with one or more durg release cells within which such drug preparation is initially held isolated from the liquid, each of said drug cells having means for emptying its contents of drug preparation into said drug dissolution space after insertion thereof in the drug release device. Such device can be used for sequential emptying of a drug preparation from two or more such drug cells whereby a parenteral liquid dissolves the drug. Also described are a parenteral drug delivery system, a drug cell, and a method of parenteral drug delivery.

Drug release device

The invention relates to a method and a capsule for the storage and mixing of the two co-reactive basic materials for dental amalgam. The capsule comprises an elastically bendable length of tube bent into V-shape with the arms each forming chambers and with the tip between the arms forming a point of separation between the chambers. Each of the basic materials is accommodated and stored in its own chamber and can be mixed by straightening out the length of tube, the ends of which are sealed, so that the point of separation is opened up, and by shaking the length of tube in its axial direction. The invention also relates to a method in manufacturing the capsule in which the tube length prior to bending into V-shape is pre-shaped in one section at the center of the length of the tube by providing two transverse points of compression which are mutually separated by an intervening section.

Method and capsule for storing and mixing the two co-operative basic

A disposable container for forming the end wall of the open end of a barrel of a syringe and for being retained thereon by the resilient interaction of a surface of the barrel and the resilient periphery of a circumferential flange at the intersection of a substantially rigid first wall portion and a flexible second wall portion of the container. Preferably the resilient periphery flexes when pressed into the barrel and then springs out to engage an annular channel-like area in the barrel.

Disposable container for a syringe

A syringe with a plunger reciprocable therein has a collapsible container removably attached to the discharge end of the barrel. The container can be collapsed by means of the plunger. The stroke volume of the plunger between displaced positions thereof corresponding to the container being empty and filled, respectively, is substantially equal to the volume of the container.

Syringe

In a syringe comprising a barrel and a plunger reciprocably mounted therein the end wall of the barrel at the discharge end thereof is formed by a disposable container removably attached to the barrel. A flexible wall portion of the container facing the plunger is moved towards and away from a rigid wall portion of the container by the reciprocating movement of the plunger in order to decrease and increase, respectively, the interior volume of the container.

Syringe and disposable container therefor

A self-closing closure for a tube or package having a resilient wall for dispensing flowable material upon the application of pressure on the tube, utilizing a relatively stiff spider for supporting an outwardly extending valve stem having a closed outer surface and a diaphragm member having its periphery interconnected with the periphery of the spider to form a closure unit and its inner portion forming a valve with the valve stem. The diaphragm member is formed with a relatively thick flange substantially parallel with the walls of the tube for interconnection therewith, a relatively thin, resilient planar portion extending inwardly toward the stem, and a substantially tubular portion surrounding the stem and terminating in an open lip which makes a close, sliding fit with the outer surface of the stem. The resilient, planar portion of the diaphragm member is normally concave, being formed with an unstressed negative angle of substantially 5.degree. to 15.degree. with a plane perpendicular to the longitudinal axis of the tube. When assembled with the spider, the stem interacts with the lip of the tubular portion of the diaphragm member to reduce the negative angle by about 2.degree. and to form a secure closure in the rest position of the planar portion. When pressure on the tube above a predetermined value is applied, the planar portion of the diaphragm member is forced outwardly by the contents of the tube to a convex shape having a positive angle not to exceed 8.degree., carrying the lip of the tubular portion away from the stem and opening the valve. Upon release of the pressure on the tube, the planar portion of the diaphragm member automatically returns to its rest position having a concave configuration with respect to the flange and the tube and securely closing the tube.

Growing community of inventors

Mjolby, Sweden

Nils B Nilson