Sun Pharmaceutical Industries Limited

Sun Pharma Advanced Research Company Limited

Nileshkumar Sureshbhai Patel

Rajamannar Thennati

Srinivasu Kilaru

Muthukumaran Natarajan

Thennati Rajamannar

Kilaru Srinivasu

Ashok Punju Borase

Mehul Chandrakatbhai Bhatt

Chinnapillai Rajendran

The present invention relates to an improved process for preparing morphinane analogues of formula 1 wherein the substituents R, R, R, R, R, Rand Y have the meanings as defined in the specifications.

Process for the preparation of morphinane analogues

The present invention relates to an improved process for preparing morphinane analogues of formula (1) 

Stable polymorphic forms III, IV and substantially amorphous form of an anticonvulsant, tiagabine hydrochloride.

Stable polymorphic forms of an anticonvulsant

The present invention provides a process for the preparation of crude 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile base with substantially low levels of impurities by arresting the formation of substantial amount of carboxamide impurity, high molecular weight impurities and suppressing the formation of desmethylcitalopram besides taking the cyanide exchange reaction to near completion and thus avoiding an extensive and expensive purification process.

Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile

The present invention provides a process for decreasing the content of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran, a compound of formula 1, wherein X is halogen,by converting to a compound of formula 3,comprising subjecting [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran present as impurity in crude 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile to hydrogenolysis.

Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid

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Baroda, India

Nileshkumar Sureshbhai Patel