University System of Maryland

Nilesh N Mistry

Warren D D'Souza

Hao H Zhang

Hamid R Ghaffari

Xinsheng Cedric Yu

Byong Yong Yi

Giovanni Lasio

A method and apparatus for irradiation therapy using voxel based function measurements of organs-at-risk (OAR). The method includes determining size and location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that relate to utility of tissue type at each voxel. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure fj at each voxel of the subset based on a corresponding value of the measurements. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function that is based on a computed dose delivered to an OAR voxel multiplied by the utility measure fj for that voxel summed over all voxels.

System and method for irradiation therapy using voxel based functional measurements of organs at risk

Techniques for suppression of motion artifacts in medical imaging include obtaining projections at different times within a time interval from a medical imaging system operating on a subject. A stationary projection is determined for a first subset of the projections in which a signal source and detector array of the imaging system are in a first configuration relative to the subject. An image of the subject based on the stationary projection is displayed. For any subset, the stationary projection is a minimum value for each pixel among the subset of projections if a signal passing through a moving object of interest inside the subject is expected to cause an increase in a pixel value. Alternatively, the stationary projection is a maximum value for each pixel among the subset of projections if the signal passing through the object of interest is expected to cause a decrease in a pixel value.

Techniques for suppression of motion artifacts in medical imaging

A method and apparatus for irradiation therapy using voxel based function measurements of organs-at-risk (OAR). The method includes determining size and location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that relate to utility of tissue type at each voxel. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure &#x192;j at each voxel of the subset based on a corresponding value of the measurements. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function that is based on a computed dose delivered to an OAR voxel multiplied by the utility measure &#x192;j for that voxel summed over all voxels.

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Cary, NC, United States of America

Nilesh N Mistry