Piramal Enterprises Limited

Nilambari Nilkanth Yewalkar

Sanjay Kumar

Vijaykumar Bhagwan Deore

Kalpana Sanjay Joshi

Rajiv Sharma

Sapna Parikh

Asha Adrian Kulkarni-Almeida

Maggie Rathos

Nilesh Dagia

Mandar Bhonde

Amol Arun Padgaonkar

The present invention relates to substituted phenyl alkanoic acid compounds designated as the compound of Formula (I) (as described herein) or a tautomer, a stereoisomer, a geometrical isomer, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, a prodrug, a polymorph, an N-oxide, a S-oxide or a carboxylic acid isostere thereof; which are GPR120 agonists. The present invention also relates to a pharmaceutical composition of compound of Formula (I) for the treatment of diseases or disorder mediated by GPR120.

Substituted phenyl alkanoic acid compounds as GPR120 agonists and uses thereof

The present invention relates to pyridyl derivatives capable of inhibiting phosphatidylinositol-3-kinase (PI3k), mammalian target of rapamycin (mTOR) and/or hypoxia inducible factor 1&#x3b1; (HIF-1&#x3b1;) mediated signaling. Also disclosed are processes for preparation of the pyridyl derivatives, and their use in the manufacture of pharmaceutical compositions for the treatment of clinical conditions caused by deregulation of signaling pathways selected from one or more of PI3K, mTOR and HIF-1&#x3b1; pathways. The pyridyl derivatives are also useful for the treatment of conditions or disorders mediated by TNF-&#x3b1;.

Pyridyl derivatives, their preparation and use

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Pune, India

Nilambari Nilkanth Yewalkar