Pharmacyclics, Inc.

Boise State University

Missouri State University

Nikolay Gerasimchuk

Darren Magda

Dale Miles

Cheryl Lepp

Mikhail Y Berezin

Henry A Charlier, Jr

A system and method for producing a near-infrared sensitive luminescent materials beyond 1000 nm is disclosed. The method includes reacting K[PtCl] and cyanoxime ligands in an aqueous solution to achieve dark-green one-dimensional coordination-polymeric materials having a molecular formula of PtL, wherein L are the cyanoxime ligands having a molecular formula of NC&#x2014;C(&#x2550;NOH)&#x2014;R with R being an electron withdrawing group such as: N'N-diethylacetamide, N-piperidine, N-morpholyl, 2-pyridine, benzoyl, or N-pyrrolidine.

Near-infrared emitters

Compositions of matter for treating cancer patients are used to prevent or limit cardiotoxicity during or after treatment with anthracycline drugs, and to prevent or lower resistance to anthracycline drugs, both of which are believed to be caused by the human enzyme carbonyl reductase. Preferred embodiments comprise a pharmaceutical composition comprising compounds having halogenated (or pseudo-halogenated) aryl groups, preferably halogenated (or pseudo-halogenated) arylcyanooximes or phenylcyanooximes and derivatives or analogs thereof, including those comprising &#x2014;CL or &#x2014;F, or other substituents on an aryl/phenyl ring. The preferred composition of arylcyanooxime(s) may be administered in a pharmaceutical composition also comprising at least one anthracycline compound, or may be administered separately from the at least one anthracycline compound.

Cyanooxime inhibitors of carbonyl reductase and methods of using said inhibitors in treatments involving anthracyclines

Novel coordination polymers, their pharmaceutical formulations, useful for treating atheroma, tumors and other neoplastic tissue, as well as other conditions that are responsive to the induction of targeted oxidative stress, are disclosed.

Texaphyrin coordination compounds and uses thereof

Growing community of inventors

Springfield, MO, United States of America

Nikolay Gerasimchuk