Eth Zurich

Cemm Forschungszentrum Fur Molekulare Medizin Gmbh

Eidgenossische Technische Hochschule Zurich

Eidgenoessische Technische Hochschule Zurich

Nikolaus Krall

Jorg Scheuermann

Dario Neri

Jörg Scheuermann

Willy Decurtins

Moreno Wichert

Gregory Vladimer

Berend Snijder

The invention relates to a multiwell imaging plate and a method for incubating non-adherent cells. The multiwell imaging plate includes multiple wells, at least some of the wells having a first chamber, a second chamber arranged on top of the first chamber, and a disturbance blocking structure provided between the first chamber and the second chamber. The first chamber is formed by one or more first sidewalls and a bottom wall while the second chamber is formed by one or more second sidewalls and includes an opening for introducing liquids. The disturbance blocking structure includes at least one through hole that provides a liquid connection between the first and second chambers.

Multiwell imaging plate and method for incubating non-adherent cells

A binding moiety (B) for Carbonic Anhydrase IX (CAIX), the binding moiety comprising: The binding moiety is univalent, bivalent, or multivalent. A targeted therapeutic agent may comprise the binding moiety. The invention also includes a method for treating a disease expressing elevated levels of CAIX by administering the targeted therapeutic agent.

Small molecule drug conjugates

A targeted therapeutic agent comprising a compound of formula I:B-L-D&#x2003;&#x2003;(I),wherein: B is a low molecular weight binding moiety for Carbonic Anhydrase IX (CAIX); D is a drug moiety; and L is a linker group that undergoes cleavage in vivo for releasing said drug moiety in an active form. The drug moiety is suitably a cytotoxic agent for targeted delivery to cancer cells expressing CAIX. The binding moiety B suitably comprises a sulfonamidothiadiazole moiety. The binding moiety B may comprise one, two or more groups capable of binding to CAIX. The linker group suitably comprises a disulfide bond and/or a triazole group and/or a cleavable peptide group.

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Vienna, Austria

Nikolaus Krall