Boehringer Ingelheim Gmbh

Dr. Karl Thomae Gmbh

Nikolaus Kaubisch

Rudolf Hurnaus

Wolfgang Grell

Robert Sauter

Gerhart Griss

Bernhard Eisele

Matyas Leitold

Eckhard Rupprecht

Joachim Kahling

There are described novel carboxylic acid derivatives of the formula ##STR1## and derivatives of the formula ##STR2## and the addition salts thereof, which exhibit an effect on the intermediary metabolism. Furthermore, the compounds of Formula Ia as well as the compounds of Formula I possess blood-sugar lowering properties.

Carboxylic acid amides and pharmaceutical compositions containing them

This invention relates to novel indole derivatives of formula ##STR1## and the non-toxic, pharmacologically acceptable salts thereof. These compounds exhibit desirable pharmacological properties, especially lipid-level lowering and anti-atherosclerotic activity. The compounds of the invention may be prepared by, for example, alkylation of a corresponding hydroxy indole.

2[3-(4-Chlorophenyl)-1,2-dimethyl-1H-indol-5-yloxy]-2-methyl propanoic

Compounds of the formula ##STR1## wherein R.sub.1 is straight or branched alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, phenylalkyl, phenylalkenyl, pyridyl or ##STR2## where X, Y and Z are each hydrogen, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms,

Derivatives of biphenyloxy-lower alkanoic acids, salts thereof and their

Biphenyloxy derivatives and antihyperlipidemic use

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Biberach, Germany

Nikolaus Kaubisch