Schering Aktiengesellschaft

Bayer Schering Pharma Ag

Shering Ag

Nikolaus Heinrich

Rolf Bohlmann

Rosemarie Lichtner

Gerhard Sauer

Karl-Heinrich Fritzemeier

Yukishige Nishino

Martin Schneider

Karsten Parczyk

Jorg Kroll

Helmut Hofmeister

Dieter Bittler

Richard Rees

Christa Hegele-Hartung

Gerhard Johann

Peter Wegner

Clemens Kotter

Gerhard Tarara

Erhard Nordhoff

Gabriele Kruger

Christoph Harde

Anita Kruger

Josef Heindl

Jens Hoffmann

Peter Strehlke

Hans-Peter Muhn

Manfred Lehmann

Rolf Krattenmacher

Hermann Kunzer

Klaus Schoellkopf

Ludwig Zorn

Rolf Jautelat

Graham Peter Jones

Orlin Petrov

Andreas Reichel

Monika Lessl

Christa Hegelehartung

Hermann K&uuml;nzer

The invention relates to 17&#x3b1;-alkyl-17&#x3b2;-oxy-estra-1,3,5(10)-trienes that have an antiestrogenic action with general formula I. In addition, the invention also relates to 17-oxo-estra-1,3,5(10)-trienes as well as 17&#x3b2;-hydroxy-estra-1,3,5(10)-trienes as intermediate products in the production of the estratrienes according to the invention. The invention also relates to the use of 17&#x3b1;-alkyl-17&#x3b2;-oxy-estratrienes for the production of pharmaceutical agents as well as pharmaceutical preparations that contain at least one 17&#x3b1;-alkyl-17&#x3b2;-oxy-estratriene as well as at least one pharmaceutically compatible vehicle.

17&#x3b1;-alkyl-17&#x3b2;-oxy-estratrienes and intermediate products for their production, use of the 17&#x3b1;-alkyl-17&#x3b2;-oxy-estratrienes for the production of pharmaceutical agents as well as pharmaceutical preparations

17&#x3b1;-ALKYL-17&#x3b2;-OXY-ESTRATRIENES AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION, USE OF THE 17&#x3b1;-ALKYL-17&#x3b2;-OXY-ESTRATRIENES FOR THE PRODUCTION OF PHARMACEUTICAL AGENTS AS WELL AS PHARMACEUTICAL PREPARATIONS

This invention describes a 11&bgr;-long-chain-substituted estratriene of general formula (I), in which R is a long-chain radical that has a nitrogen atom and optionally a sulfur atom, which in addition can be functionalized in the terminal position with a perfluoroalkyl group or an optionally substituted arly radical. The compound can have antiestrogenic or tissue-selective estrogenic properties and be suitable for the production of pharmaceutical agents.

11&bgr; LONG-CHAIN SUBSTITUTED ESTRATRIENES, METHOD FOR THEIR PRODUCTION, PHARMACEUTICAL PREPARATIONS CONTAINING SAID 11&bgr; LONG-CHAIN SUBSTITUTED ESTATRIENES, AND THEIR USE FOR PRODUCING MEDICAMENTS

11&bgr;-HALOGEN-7&agr;-SUBSTITUTED ESTRATRIENES, PROCESS FOR THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS THAT CONTAIN THESE 11&bgr;-HALOGEN-7&agr;-SUBSTITUTED ESTRATRIENES AS WELL AS THEIR USE FOR THE PRODUCTION OF PHARMACEUTICAL AGENTS

Nonsteroidal gestagens

This invention describes the new 7&agr;-(5-methylaminopentyl)-estratrienes of general formula I

7 &agr;-(5-methylaminopentyl)-estratrienes, process for their production, pharmaceutical preparations that contain these 7 &agr;(5-methylaminopentyl)-estratrienes as well as their use for the production of pharmaceutical agents

This invention describes new, substituted 7&agr;-(&egr;-aminoalkyl)-estratrienes of general formula I

7&agr;-(xi-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7&agr;-(xi-aminoalkyl-estratrienes as well as their use for the production of pharmaceutical agents

This invention describes the new, nonsteroidal gestagens of general formula I

This invention describes new, substituted 7.alpha.-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organic and inorganic acids. The new compounds represent compounds with very strong antiestrogenic action. The compounds according to the invention are, on the one hand, pure antiestrogens, or, on the other hand, antiestrogens with estrogenic partial action. Based on this spectrum of action, the new compounds are highly suitable for the production of pharmaceutical agents for tumor therapy and hormone replacement treatment.

7.alpha.-(.xi.-aminoalkyl)-estratrienes, process for their production,

The invention relates to new substituted .alpha.-pyrimidinyloxy(thio)- and .alpha.-triazinyloxy(thio)carboxylic acid derivatives of general formula I ##STR1## in which A, R.sup.1-3, X and Y have the meanings given in the description, processes for their preparation and their use as herbicides, fungicides and plant growth regulants.

Herbicidal dimethoxy pyrimidinyloxy-fluorinated acids and salts

The invention relates to new 2-pyrimidinyl- and 2-triazinylacetic acid derivatives of general formula I ##STR1## in which A, R.sup.2-5 and X have the meanings given in the description, processes for their preparation and their use as herbicides, fungicides and plant growth regulants.

Substituted 2-pyrimidinyl-acetic acid derivatives, and their use as

2-triazinylacetics acid derivatives, and their use as herbicides,

The invention relates to new substituted pyrimidinyloxy(thio)- and triazinyloxy(thio)acrylic acid derivative of general formula I ##STR1## in which A, G, R.sup.1-3, X and Y have the meanings given in the description, processes for their preparation and their use as herbicides, fungicides and plant growth regulants.

Substituted pyrimidinyloxy(thio)- and triazinyloxy (thio)acrylic acid

Growing community of inventors

Berlin, Germany

Nikolaus Heinrich