City of Hope

The University of Manchester

National and Kapodistrian University of Athens

University of Dundee

Nikolaos Lougiakis

Nicole Pouli

David A Horne

Sangkil Nam

Ravi Salgia

Panagiotis Marakos

Vassilis Gorgoulis

Paul Townsend

Panayiotis Marakos

Nikolaos Kastrinakis

Alexios-Leandros Skaltsounis

Alexios Leandros Skaltsounis

Nicolas Gaboriaud-Kolar

Vassilis G Gorgoulis

Athanassios Kotsinas

Russell Petty

Panagiotis Gerolymatos

Konstantinos Evangelou

Ilias Christos Tzortzatos

A compound, or a salt or solvate thereof, according to formula I as defined herein and pharmaceutical composition comprising said compound. Compounds of formula I are capable of detecting senescence. As such, these compounds are useful in methods of detecting or imaging senescent cells or extracts thereof or senescence in a subject or a biological sample taken from a subject.

Imaging compounds for detecting or imaging senescent cells

Disclosed herein inter alia are compositions and methods for treating cancer using thioindirubin derivatives.

Thioindirubins

Disclosed herein, inter alia, are pyridopyrazines and methods of using the same.

Pyridopyrazine compounds and uses thereof

The present disclosure relates to compounds of the formula (1) that function as senescent cell detectors: wherein the SBB analogues refer to de novo synthesized derivatives with structural similarity to the Sudan Black B dye, L is an appropriate chemical bond and hapten is biotin, or digoxigenin, or 2,4-dinitrophenol, or fluorescein, but more preferably biotin. The present invention also relates to processes for the preparation of these compounds, to their use in the detection of senescent cells, to methods of detecting senescence in cells and to kits comprising said compounds. 

Compounds, linked with haptens, for the detection of senescent cells

The present disclosure relates to de novo synthesized, chemical compounds of the formula (1) or (2) that function as senescent cell detectors wherein R, R, R, Rand Z are as defined herein. The present invention also relates to processes for the preparation of these compounds, to their use in the detection of senescent cells, to methods of detecting senescence in cells and to kits comprising said compounds. The compounds have the ability to react with lipofuscin, in an analogous manner to the histochemical dye Sudan Black B (SBB). 

Compounds for the detection of senescent cells

Growing community of inventors

Athens, Greece

Nikolaos Lougiakis