Veloxis Pharmaceuticals A/s

Egalet Ltd.

Veloxis Pharmaceuticals Inc.

Biograil Aps

Nikolaj Skak

Per Holm

Martin Rex Olsen

Karsten Lindhardt

Torben Elhauge

Gina Engslev Fischer

Peter Holm Tygesen

Jan Martin Overgard

Georg Boye

Liselotte Hansen

The invention relates to a stable pharmaceutical composition comprising comprising a solid dispersion of tacrolimus in a vehicle further comprising e stabilizing agent capable of providing a pH below 7 in the composition, as measured after re-dispersion in water, and preventing or reducing the formation upon storage of major degradation products of tacrolimus, in particular the 8-epitacrolimus.

Stabilized tacrolimus composition

The present disclosure relates to a delivery device capable of delivering compositions. In some embodiments, the delivery device may deliver compositions to the gastrointestinal tract. In some embodiments, the compositions contain active drug substances. In some embodiments, the active drug substances are low permeable active drug substances.

Oral delivery of active drug substances

The invention relates to a stable pharmaceutical composition comprising comprising a solid dispersion of tacrolimus in a vehicle further comprising a stabilizing agent capable of providing a pH below 7 in the composition, as measured after re-dispersion in water, and preventing or reducing the formation upon storage of major degradation products of tacrolimus, in particular the 8-epitacrolimus.

The present disclosure relates to pharmaceutical compositions that are abuse resistant and may also provide controlled release. The present disclosure also relates to the use of pharmaceutical compositions in the treatment of pain.

Abuse deterrent pharmaceutical compositions for controlled release

Abuse-deterrent pharmaceutical compositions for controlled release

Growing community of inventors

Virum, Denmark

Nikolaj Skak