Novo Nordisk A/s

Nikolaj Eusebius Jakobsen

Nikolaj Frogner Krusell

Preben Mikael Nielsen

Michael Ejstrup Hansen

Jonas Torry-Smith

Ramin Nateghi Elahi

Laurits Hoejgaard Olesen

Jens Christian Andersen

Carsten Schau Andersen

Christian Peter Enggaard

Steffen Hansen

Claus Schmidt Møller

Gregory A Kirkos

Simon Roervig

Ebbe Kiilerich

Asger Voss Christiansen

Jakob Oest Wielandt

Lee Higson

Per Einar Pontus Holm

Claus Urup Gjødesen

Dave Szakelyhidi

Matthew William Haave

Blake Matsuzaki

Ian McLoughlin

Simon RØRVIG

Ian Mcloughlin

Jonas Smith- Torry

The invention relates to an injection device wherein the drive element transferring rotation to the piston rod is divided into two elements which are able to move axially in relation to each other such that the drive mechanism can be released to allow the user to reset the piston rod and change the cartridge.

Reusable torsion spring driven injection device

The present invention provides a piston rod displacement mechanism for a pen injection device, comprising: a tubular housing () extending along a reference axis and comprising an interior housing surface () with a first engagement structure (), a nut member () fixed within the tubular housing (), a piston rod () comprising a first non-self-locking thread () having a first thread direction and a first thread pitch and being engaged with the nut member (), and a second non-self-locking thread () superposed on the first non-self-locking thread (), the second non-self-locking thread () having a second thread direction and a second thread pitch, and a dose dial sleeve () operable to advance the piston rod () in the nut member (), the dose dial sleeve () comprising an exterior sleeve surface () with a second engagement structure () being in sliding engagement with the first engagement structure (), and an interior sleeve surface () with a third engagement structure () being engaged with the second non-self-locking thread (). One of the first engagement structure () and the second engagement structure () comprises a closed-circuit track configuration and the other of the first engagement structure and the second engagement structure comprises a track follower, and the closed-circuit track configuration comprises a helical track portion () having a helical track direction equaling the second thread direction and a helical track pitch equaling the second thread pitch, and an axial track portion () extending between a distal track end () and a proximal track end () and being connected to the helical track portion () at the distal track end ().

Piston rod drive mechanism

The present invention provides a drug injection device (″) comprising a first element () and a second element (″) configured to undergo movement relative to each other corresponding to an action performed on or by the drug injection device (″), wherein the first element () comprises serially disposed protrusions (), and wherein the second element (″) comprises a second element base and a deflectable transducer (″). The deflectable transducer (″) defines a base portion attached to the second element base, and a deflectable portion () configured for sequentially cooperating with the plurality of protrusions (), wherein a processor () is electrically connected with the deflectable transducer (″) to register activation signals. The deflectable transducer (″) comprises a carrier foil () that extends from the base portion to the tip end of the deflectable portion (), and a sensor element comprising a strain sensitive material () disposed on the carrier foil () and extending from the base portion towards the tip end of the deflectable portion (), wherein the carrier foil (), between the base portion and tip end of the deflectable portion (), comprises a non-supported portion having said strain sensitive material () disposed at least partly along the non-supported portion.

Drug injection device with deflectable transducer

A dosage sensing module for or in a pen drug delivery device and comprising a power source unit, a processor unit and a dosage sensor unit with a first sensor part adapted to be fixed to a part not rotating during dose expelling and comprising a flexible printed circuit board sheet on which a pattern of individual electrical conductive sensor areas are arranged. The sensor unit further comprises a second sensor part adapted to be fixed to the piston rod to follow the rotation thereof during dose expelling. The second sensor part comprises individual structures that together with the conductive sensor areas are adapted to, upon relative rotational movement between the first and second sensor part, provide electrical signals to a processor unit indicative of the relative rotational position between the first and second sensor part.

Rotary dosage sensing module for and in a disposable pen drug delivery device

The present invention provides a drug injection device () for delivering multiple doses of drug, comprising: a housing () extending along a main axis, a dose expelling mechanism comprising a piston rod () configured to move relative to the housing () from a first position to a second position to cause ejection of a dose of drug, the piston rod () extending between a proximal piston rod end and a distal piston rod end and comprising a dosing track (), the piston rod () further being movable relative to the housing () from an initial pre-use position to a final end stop position to cause accumulated ejection of a predefined total dose, a dosing track follower () fixed with respect to the housing () and adapted to travel the dosing track () during dose ejection, a dose setting mechanism operable to set the dose to be ejected by the dose expelling mechanism, electronic means () for registering a dose setting operation and for registering a dose size of an ejected dose, and a display () adapted to indicate a size of a current set dose, the electronic means () being configured to provide a first type of update of the display () responsive to dose changing operations of the dose setting mechanism, wherein the electronic means () is further configured to calculate a current accumulated dose from the dose sizes of registered ejected doses to thereby provide an updated value of a total amount of drug ejected, determine a current remaining dose by comparing the current accumulated dose and the predefined total dose, and provide a second type of update of the display () when during a dose increasing operation of the dose setting mechanism the current set dose exceeds the current remaining dose, the second type of update being different from the first type of update, and wherein the final end stop position is defined by a track end configuration of the dosing track () between the proximal piston rod end and the distal piston rod end.

End-of-content mechanism

The invention provides a pen-type injection device () with a piston rod brake mechanism for improving the determination of an expelled dose.

Piston rod brake mechanism

A drug delivery system comprises an indicator element and a sensor system. The indicator element is arranged to rotate relative to a reference component and corresponding to a reference axis and comprises a plurality of dipole magnets. The sensor system comprises a plurality of magnetometers arranged non-rotational relative to the reference component and adapted to determine continuous magnetic field values from the plurality of dipole magnets, as well as processor means configured to determine on the basis of measured values from the plurality of magnetometers a rotational position and/or a rotational movement of the indicator element.

Drug delivery system with multipolar magnet and sensor system

A drug delivery system comprises means to create a log of expelled dose amounts of drug. Stored dose amounts determined within a given time period are combined to a single combined dose amount. The given time period is initiated by a detected expelling event taking place (i) a given amount of time after a previous detected expelling event, or (ii) after a given detected action. By this arrangement it is possible to create a log corresponding to what a user considers to be a single dose, i.e. combining 'split doses' to create a single log entry for a per se split dose.

Logging device adapted to combine doses

A drug delivery system comprises an indicator element and a sensor system. The indicator element is arranged to rotate relative to a reference component and corresponding to a reference axis and comprises a magnetic ring. The sensor system comprises a plurality of magnetometers arranged non-rotational relative to the reference component and adapted to determine continuous magnetic field values from the plurality of dipole magnets, as well as processor means configured to determine on the basis of measured values from the plurality of magnetometers a rotational position and/or a rotational movement of the indicator element.

Drug delivery system with magnetic ring and sensors arranged in a ring pattern

A logging device adapted to be attached to a pen drug delivery device () and capture a property value related to the dose amount of drug expelled from the drug delivery device during an expelling event, the logging device comprising a bore in which a snap lock with a flexible wire portion is arranged circumferentially in the bore, the wire being adapted to be moved laterally by a projection on the pen device and subsequently snap inwardly when the pen device is inserted axially in the bore. In this way an axial snap lock is provided between the logging device and the drug delivery device.

Accessory device with snap feature

A system comprising a sensor assembly adapted to measure a magnetic field, and a mechanical assembly comprising an indicator element with a magnet moving together therewith, the magnet being configured to generate a spatial magnetic field which relative to the sensor assembly varies corresponding to the spatial position and orientation of the magnet, wherein the indicator element is adapted to both rotate and move axially during operation of the assembly. Processor means is configured to determine on the basis of measured values both a rotational position and an axial position of the indicator element.

Dose logging device for a drug delivery device

A medial assembly comprises a logging first unit adapted to be mounted on a drug delivery device second unit from a fully un-mounted to a fully mounted position along a path. The first unit comprises a switch operatable between an off- and an on-state when the first unit is mounted on the second unit, the switch being in the on-state when the first unit is mounted within a first distance from the fully mounted position, and in the off-state when the first unit is mounted outside the first distance from the fully mounted position, and a snap lock operatable from an initial state through an expanded state to a snap-in state when the first unit is mounted on the second unit, the snap lock being in the snap-in state when the first unit is mounted within a second distance from the fully mounted position, the second distance being shorter than the first distance. By this arrangement it is ensured that the switch will be in the on-state before the snap lock is in the snap-in state.

Accessory device with mounting safety feature

The invention relates to a pen-shaped torsion spring driven injection device for apportioning set dose of a liquid drug. A piston rod having an external thread is driven forward by a rotatable piston rod guide engaging the piston rod. The piston rod guide is rotated by a torsion spring encompassed between the housing and the piston rod guide. A scale drum having a thread engaging the external thread of the piston rod is provided, and the scale drum is rotated up and down the piston rod by a proximal located rotatable dose setting member cooperating with the scale drum. The scale drum thus move helically when rotated as the piston rod is held inrotatable during dose setting.

Pen-shaped torsion spring driven injection device

A drug delivery assembly comprises a drug delivery device, an electronic dose logging module releasably attachable to the drug delivery device, and a cap releasably attachable to the logging module to cover an outlet portion of a mounted drug reservoir. The logging module and the drug delivery device comprise mating snap coupling means. The logging module comprises locking means acting on the locking module snap coupling means, wherein the locking means is actuated from the unlocked to the locked state when the cap is attached to the logging module in a first direction, and the locking means is actuated from the locked to the unlocked state when the cap is detached from the logging module in a second direction opposed to the first direction.

Drug delivery device and logging module assembly

A medical delivery system comprising a container which is adapted to be fastened to a dosing assembly. One of the container and the dosing assembly comprises a rotatable element adapted to cooperate with the other one of the container and the dosing assembly, so as to lock/fasten the container to the dosing assembly. Furthermore, the present invention relates to a container and a dosing assembly for use in the medical delivery system.

Growing community of inventors

Soeborg, Denmark

Nikolaj Eusebius Jakobsen