Nanoscale Combinatorial Synthesis, Inc.

University of California

Mayo Foundation for Medical Education and Research

3100 Central Expressway LLC

Piksci Inc.

Nikolai Sepetov

Robert J Greenhouse

Sergei Romanov

Olga L Issakova

Kevan M Shokat

Heinz W Gschwend

Chao Zhang

James A Ostrem

Eric J Kunkel

Alexander Keith Stewart

Artem Plekhov

Brian Rich

Wen Yang

Zhiwei Tong

Stephen A Baum

A compound and/or a pharmaceutically acceptable salt thereof has the following formula A: These compounds can be PIKfyve kinase inhibitors.

Fused triazolo-pyrimidine compounds having useful pharmaceutical application

A compound and/or a pharmaceutically acceptable salt thereof has the following formula A: These compounds can be PIKfyve kinase inhibitors. 

This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to treat hematological malignancies, inflammation diseases, and autoimmune disorders.

Small molecule inhibitors of G protein coupled receptor 6 kinases polypeptides

The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition.

Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents

The present invention includes methods for generating combinatorial libraries on solid phase supports in which increased productivity is achieved by pooling all common steps in synthesis without using a tracking or coding system to record the synthetic history of each compound. Methods for generating combinatorial libraries in which containers with random mixtures of solid phase particles are divided and combined together in non-random ways without the exchange of particles between containers are also provided. Various products are optionally produced in multi-stage syntheses according to the invention, such as oligomers and synthetic non-repetitive organic molecules. The methods additionally relate to the identification of each library component without adding extra synthetic, physical, optical, or electronic encoding steps during library synthesis. Combinatorial synthetic systems are also provided.

Nonredundant split/pool synthesis of combinatorial libraries

Methods of identifying predicted or actual structures of members of a chemical or physical library are provided. The methods provide for the direct identification of compound structure following combinatorial synthesis using molecular mass measurements of individual compounds, thereby eliminating the necessity of encoding synthetic steps. The analysis of mass spectrometric data for sets of related compounds reveals compounds that are missing in a group of related compounds and identifies compounds that do not belong to a group of related compounds due to unexpected chemical, physical, or biological transformations. The methods may be applied to any group of compounds originating from chemical reactions where one reactant is common to the synthetic transformation. One particular application of these methods is in the analysis of the products of combinatorial synthesis. Systems, computer programs products, and kits are additionally provided.

Structure identification methods using mass measurements

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Los Gatos, CA, United States of America

Nikolai Sepetov