Nanoform Finland Oyj

Helsingin Yliopisto

Intelligent Pharmaceutics Ltd Oy

Åbo Akademi Åbo Akademi University

Niklas Sandler

Ivan Kassamakov

Anton Nolvi

Tapani Viitala

Johan Nyman

Jouko Yliruusi

Edward Hæggström

Osmo Antikainen

Tuomo Ylitalo

Tatiana Danilova

Nikolay Houbenov

Eric Kissi

Martti Kaasalainen

The disclosure relates to methods for crystallization of active pharmaceutical ingredients (APIs), wherein the crystallization and crystal growth is controlled. According to the method solid amorphous nanosized API and an aqueous solution comprising one or more polymers and/or copolymers are contacted so as to form a suspension comprising nanosized API in crystalline form.

Method for crystallization of active pharmaceutical ingredients

An artifact for determining resolution of imaging based on electromagnetic radiation, mechanical waves, or both is presented. The artifact includes a substrate and layers on top of the substrate. The layers include organic material and are stacked on each other in a partially overlapping way so that an edge of a first one of the layers is arranged to intersect with an edge of a second one of the layers. The layers constitute a three-dimensional surface topography where a groove defined by the edges of the first and second ones of the layers is tapering towards a point of intersection between the edges. The resolution is a minimum width of the tapering groove which is revealed by the imaging so that a pre-determined criterion is fulfilled.

Artifact for determining resolution of imaging based on electromagnetic radiation and/or mechanical waves

A method for calibrating electromagnetic radiation-based three-dimensional imaging includes: obtaining () a calibration imaging result at least partly on the basis of electromagnetic waves received from a calibration artifact, forming () calibration data on the basis of the calibration imaging result and a known thickness profile of the calibration artifact, and correcting (), with the aid of the calibration data, an imaging result obtained at least partly on the basis of electromagnetic waves received from a sample to be imaged. The calibration artifact includes layers, for example Langmuir-Blodgett films, having pre-determined thicknesses and stacked on each other so as to achieve the pre-determined thickness profile of the calibration artifact. A three-dimensional imaging system configured to carry out the method.

Method for calibrating 3D imaging and system for 3D imaging

The invention relates to a measuring method for measuring the properties of a powder or granular sample () from the surface information of the sample. According to the method the sample is leveled for the measurement, at least one image of the surface of the sample () is taken and the properties, such as the grain-size distribution, of the sample () are determined by processing the information material by calculation. According to the invention, the sample () is made to be supported on a transparent sample plate () and an image is taken through this sample plate ().

Measuring method and system for measuring particle size and shape of powdery or grain like particles

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Helsinki, Finland

Niklas Sandler