Cornell University

Nikki Thiele

Justin Wilson

John W Babich

James M Kelly

Shashikanth Ponnala

The present technology provides compounds as well as compositions including such compounds useful in targeted radiotherapy of cancer and/or mammalian tissue overexpressing prostate specific membrane antigen (“PSMA”) where the compounds are represented by the following:

Macrocyclic complexes of alpha-emitting radionuclides and their use in targeted radiotherapy of cancer

Metal-chelating compositions having the structure (1a) wherein: R, R, R, and Rare independently selected from the following groups: (i) hydrogen atom, (ii) hydrocarbon groups (R) containing 1-12 carbon atoms; (iii) halogen atoms; (iv) &#x2014;P(R) (&#x2550;O)OH groups; (v) &#x2014;C(&#x2550;O)OH groups; (vi) &#x2014;S(&#x2550;O)OH groups; and (vii) &#x2014;OH groups, wherein Ris selected from hydrocarbon groups (R) and &#x2014;OH; Rand Rmay optionally interconnect to form Ring A fused to the ring on which Rand Rare present; Rand Rmay optionally interconnect to form Ring B fused to the ring on which Rand Rare present; wherein Ring A and Ring B are optionally and independently substituted with one or more of groups (ii)-(vii). Methods of using the above-described compositions for chelating metal ions having an atomic number of at least 56 (e.g., Ba or Ra) are also described.

Metal-chelating compositions and their use in methods of removing or inhibiting barium scale

The present technology provides compounds as well as compositions including such compounds useful for the treatment of cancers where the compounds are represented by the following formula (I) or a pharmaceutically acceptable salt thereof, wherein M is an alpha-emitting radionuclide. 

The present technology provides compounds as well as compositions including such compounds useful in targeted radiotherapy of cancer and/or mammalian tissue overexpressing prostate specific membrane antigen ('PSMA') where the compounds are represented by the following:   

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Brooktondale, NY, United States of America

Nikki Thiele