Codiak Biosciences, Inc.

Lonza Sales Ag

Other

Nikki Ross

Ke Xu

John D Kulman

Douglas E Williams

Damian J Houde

Rane A Harrison

Russell E McConnell

Kevin P Dooley

Sonya Haupt

Russell E Mcconnell

Christine Mccoy

Timothy J Soos

Raymond J Moniz

The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes. Specifically, the present invention provides methods of using the proteins for affinity purification of exosomes. It also provides methods of localizing a therapeutic peptide on exosomes, and targeting exosomes to a specific organ, tissue or cell by using the proteins. The methods involve generation of surface-engineered exosomes that include one or more of the exosome proteins at higher density, or a variant or a fragment of the exosome protein.

Preparation of therapeutic exosomes using membrane proteins

The present disclosure relates to extracellular vesicles (EVs), e.g., exosomes, comprising a payload (e.g., an antigen, adjuvant, and/or immune modulator) and/or a targeting moiety. Also provided herein are methods for producing the EVs (e.g., exosomes) and methods for using the EVs (e.g., exosomes) to treat and/or prevent diseases or disorders, e.g., cancer, graft-versus-host disease (GvHD), autoimmune disease, infectious diseases, or fibrotic diseases.

Extracellular vesicles for vaccine delivery

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Cambridge, MA, United States of America

Nikki Ross