Syntis Bio, Inc.

Codexis, Inc.

Nikki D Kruse

Vesna Mitchell

Kerryn McCluskie

Gjalt W Huisman

Jovana Nazor

Ericka Bermudez

Stephan Jenne

David Elgart

Mathew G Miller

Joyce Liu

Stephanie Sue Galanie

Nandhitha Subramanian

Kristen Jean Vallieu

Adam P Silverman

Faye Loan Du

Leann Quertinmont Teadt

Jonathan Benjamin Asfaha

Roasa Mehmood

Kierra Aleece Franklin

Subhamoy Das

The present invention provides engineered leucine decarboxylase (LDC) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered leucine decarboxylase polypeptides. In some embodiments, the engineered leucine decarboxylase polypeptides display enhanced catalytic activity, as well as reduced sensitivity to proteolysis, and/or increased tolerance to low pH environments. In some embodiments, the engineered leucine decarboxylase polypeptides are optimized to provide improved storage stability. The present invention also provides methods for the use of the compositions comprising the engineered leucine decarboxylase polypeptides for therapeutic and industrial purposes.

Engineered leucine decarboxylases

The present disclosure relates to engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The present disclosure also provides methods of using the engineered DNA polymerase polypeptides or compositions thereof for diagnostic and other purposes.

Engineered DNA polymerase variants

The present invention provides engineered methionine gamma lyase polypeptides and compositions thereof. The engineered methionine gamma lyase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH<7) conditions. The present invention also relates to the use of the compositions comprising the engineered methionine gamma lyase polypeptides for therapeutic purposes.

Engineered methionine gamma lyase variants

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San Carlos, CA, United States of America

Nikki D Kruse