The Johns Hopkins University

National Institutes of Health

Kennedy Krieger Institute, Inc.

Nikita Oskolkov

Michael T McMahon

Xiaolei Song

Justin Scot Hanes

Martin Gilbert Pomper

Tao Yu

Joel Patrick Schneider

Sridhar Nimmagadda

Wojciech Lesniak

Michael Christopher Giano

Himatkumar Patel

Kannie M Y Chan

Kannie Wai-Yan Chan

The present invention provides novel hydrogels through peptides, which are designed to self-assemble and produce magnetic resonance (MR) contrast through chemical exchange saturation transfer (CEST). The location and integrity of these gels could consequently be tracked using MR imaging. The self-assembly of the peptides into hydrogels can be brought about by a change in pH, ionic strength, temperature, and concentration of ions.

Peptide hydrogels generating chemical exchange saturation transfer MRI contrast and uses thereof

PAMAM dendrimer based CEST imaging agents, pharmaceutical compositions comprising the same and methods of uses thereof are disclosed.

PAMAM dendrimer based CEST imaging agents and uses thereof

Surface conjugated diamagnetic Chemical Exchange Saturation Transfer (diaCEST) agent carriers and methods of making and using are described herein. The particles are safe alternatives to conventional paramagnetic or superparamagnetic metal-based MRI contrast agents that are often toxic and therefore not biocompatible. The carriers described herein can provide simultaneous monitoring of multiple particle types labeled with 'multicolor' diaCEST contrast agents. In some embodiments, the carriers are micro- and/or nanoparticles. In other embodiments, the carriers are liposomes. In some embodiments, the particles and/or liposomes are mucus penetrating. In other embodiments, the particles and/or liposomes are not mucus penetrating.

Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof

Growing community of inventors

Reisterstown, MD, United States of America

Nikita Oskolkov