University of Southern California

Aesculatech, Inc.

Niki Bayat

Mark Salman Humayun

Mark Edward Thompson

Yi Zhang

John J Whalen, Iii

Paulo Falabella

Adam Griese

Rahul Janardhanan

Jose Ramirez

Andrew Bartynski

Roby Menefee

Described herein is a generalized injection device for delivering formulations of various mechanical properties to precise locations. Of particular interest is the manifestation intended for the application of a thermally responsive hydrogel to the tear duct for the purpose of occlusion, as a treatment for symptoms associated with dry eye syndrome. Further, a modular solution to the need for an injection device across a variety of applications, mechanism, and physical considerations is provided. This disclosure provides examples of methods for precise injection of low volumes, moisture retention in pre-filled injection devices, and actuation for automatic or manual injection, to name a few.

Device for controlled injection across a variety of material properties

Compositions, methods, and kits for treating dry eye and related diseases are provided. In one aspect, the present disclosure relates to administering thermoresponsive polymeric compositions to the tear duct of the subject. Administering a thermoresponsive polymeric composition to the tear duct of the subject may be useful in treating dry eye and related conditions.

Thermoresponsive polymers and uses thereof

The present disclosure describes, among other things, a thereto-responsive hydrogel comprising a PNIPAM copolymer having adhesive properties that are temperature dependent, as well as a device for administering the hydrogel, and methods for making and using the foregoing.

System for sutureless closure of scleral perforations and other ocular tissue discontinuities

The present disclosure describes, among other things, a thermo-responsive hydrogel comprising a PNIPAM copolymer having adhesive properties that are temperature dependent, as well as a device for administering the hydrogel, and methods for making and using the foregoing.

Growing community of inventors

Los Angeles, CA, United States of America

Niki Bayat