University of Pittsburgh

University of Virginia Patent Foundation

Nikhil Tasker

Peter Wipf

John S Lazo

Elizabeth Sharlow

Ettore Rastelli

The disclosure provides compounds that inhibit protein tyrosine phosphatase, such as protein tyrosine phosphatase 4 A3 (PTP4A3). The disclosure also provides pharmaceutical compositions, uses, and methods of using the compounds, such as in the treatment of cancers.

In-flow photooxygenation of aminothienopyridinones generates novel PTP4A3 phosphatase inhibitors

The disclosure provides compounds that inhibit protein tyrosine phosphatase, such as protein tyrosine phosphatase 4A3 (PTP4A3). The disclosure also provides pharmaceutical compositions, uses, and methods of using the compounds, such as in the treatment of cancers. (I), wherein X is O or NH.

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Trumbull, CT, United States of America

Nikhil Tasker