Hoffmann-la Roche Inc.

Niggi Iberg

Hans Peter Wessel

Thomas B Tschopp

Gerard Schmid

Hans P Marki

Marianne Rouge

Michael Pech

Rita Muller

Jurgen Fingerle

Alexander Chucholowski

Markus Hosang

Michel Trumtel

Compounds of the formula ##STR1## wherein n.sup.1 -n.sup.9 are each independently 0 or 1;

Sulfuric acid esters of sugar alcohols

Compounds of formulas ##STR1## wherein, B is lower alkylene or an optionally substituted aromatic ring system;

Sulfuric acid esters of amino sugars

The present invention is concerned with novel sulfuric acid esters of sugar alcohols and sugar alcohol-like compounds of the formula ##STR1## Also described are methods for the treatment and/or prophylaxis of arteriosclerotic changes in the vascular wall as well as a process for the manufacture of the compounds of formula I and their salts.

The use of compounds of the formula ##STR1## wherein R is hydrogen or a residue --SO.sub.3 M; M is a cation; and R' and R' are hydrogen or an .alpha.-glycosidically linked sulfated mono- or disaccharide residue; and at least one --SO.sub.3 M group is present per monosaccharide unit, as pharmaceutical compositions for the prevention and/or treatment of arteriosclerotic disorders and for the prevention of restenosis after invasive vascular surgery and after organ transplants.

Sulfated oligosaccharides

Sulphated O-Polysaccharide-trehaloses which can be used as medicaments, especially for the treatment of arteriosclerotic disorders.

Growing community of inventors

Basel, Switzerland

Niggi Iberg