Sterix Limited

Xenova Limited

University of Bath of Claverton Down

Nigel Vicker

Barry Victor Lloyd Potter

Atul Purohit

Michael John Reed

Dharshini Ganeshapillai

William Alexander Denny

Helen Victoria Bailey

Wesley Heaton

Joanna Mary Day

John Milton

Su Xiangdong

Adrian Folkes

Swarnalatha Akuratiya Gamage

Julie Ann Spicer

Christian Bubert

Shouming Wang

Su Xiangdon

Delphine Sophie Marion Fischer

Gillian Margaret Allan

Harshani Rithma Ruchiranani Lawrence

Christopher Mark Sharland

Ana Maria Ramos Gonzalez

There is provided a compound having Formula I wherein

Compound capable of inhibiting 17-beta hydroxysteriod dehydrogenase

There is provided a compound having Formula (I) wherein each of rings A and B is selected from five or six membered carbon rings optionally containing one or more hetero atoms selected from N, S, and O and optionally having fused thereto a further ring; X is an optional group selected from O, S, &#x2014;S&#x2550;O, &#x2014;S(&#x2550;O), &#x2014;C&#x2550;O, &#x2014;S(&#x2550;O)NR, &#x2014;C&#x2550;ONR, and &#x2014;NR, wherein n and p are independently selected from 0 and 1; Y is (R)wherein each Ris independently selected from &#x2014;NR, &#x2014;CRR, &#x2014;S(&#x2550;O)and &#x2014;C&#x2550;O; Z is selected from (i) six or seven membered ring containing carbon and at least one nitrogen, which may be optionally substituted wherein the substituents may together form further ring fused thereto; and (ii) a &#x2014;R&#x2014;NR&#x2014; group.

Heterocyclic compounds as inhibitors of 17beta-HSD3

There is provided a compound of Formula (III) wherein

17B-hydroxysteroid dehydrogenase inhibitors

A compound having Formula I wherein one of Rand Ris a group of the formula wherein Ris selected from H and hydrocarbyl, Ris a hydrocarbyl group and L is an optional linker group, or Rand Rtogether form a ring substituted with the group wherein Ris H or a substituent, and wherein X is selected from S, O, NRand C(R)(R), wherein Ris selected from H and hydrocarbyl groups, wherein each of Rand Rare independently selected from H and hydrocarbyl groups.

Compound

A compound having Formula IR&#x2014;Z&#x2014;RFormula Iwherein Ris an optionally substituted phenyl ring; Ris or comprises an optionally substituted aromatic ring; and Z is &#x2014;X&#x2014;Y&#x2014;L&#x2014; or &#x2014;Y&#x2014;X&#x2014;L&#x2014; wherein either X is selected from &#x2014;S(&#x2550;O)(&#x2550;O)&#x2014; and &#x2014;C(&#x2550;O)&#x2014;; and Y is &#x2014;NR&#x2014;; or X is selected from &#x2014;S(&#x2550;O)(&#x2550;O)&#x2014; and &#x2014;S&#x2014;, and Y is &#x2014;C(R)(R)&#x2014;; L is an optional linker; and R, Rand Rare each independently selected from H and hydrocarbyl; and wherein when Rcomprises the following structural moiety wherein Q is an atom selected from the group consisting of S, O, N and C; the compound is selected from compounds of the formulae R&#x2014;C(&#x2550;O)&#x2014;NR&#x2014;L&#x2014;R; R&#x2014;S(&#x2550;O)(&#x2550;O)&#x2014;C(R)(R)&#x2014;L&#x2014;R; R&#x2014;S&#x2014;C(R)(R)&#x2014;L&#x2014;R; R&#x2014;NR&#x2014;S(&#x2550;O)(&#x2550;O)&#x2014;L&#x2014;R; R&#x2014;NR&#x2014;C(&#x2550;O)&#x2014;L&#x2014;R; R&#x2014;C(R)(R)&#x2014;S(&#x2550;O)(&#x2550;O)&#x2014;L&#x2014;R; and R&#x2014;C(R)(R)&#x2014;S&#x2014;L&#x2014;R.

11&#x3b2;-hydroxysteroid dehydrogenase inhibitors

A compound which is a benzo[a]phenazine-11-carboxamide derivative of formula (I) wherein each of Rto R, which are the same or different, is selected from hydrogen, halogen, hydroxyl, C&#x2013;Calkoxy which is unsubstituted or substituted, heteroaryloxy, C&#x2013;Calkyl which is unsubstituted or substituted, nitro, cyano, azido, amidoxime, COR, CON(R), OCON(R), SR, SOR, SOR, SON(R), N(R), NRSOR, N(SOR)NR(CH)CN, NRCOR, OCORor COR; These compounds are inhibitors of topoisomerase I and/or topoisomerase II and can be used to treat tumours, including tumours which express MDR.

Pharmaceutical compounds

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Slough, United Kingdom

Nigel Vicker