Cambridge Enterprise Limited

Prokarium Limited

Nigel Slater

Thomas Bennett

David Fairen-Jimenez

Alexander Daniel Edwards

Claudia Orellana-Tavra

Emma Baxter

Michelle Teplensky

Anthony Cheetham

Alexander Edwards

The invention provides an amorphous metal-organic framework for use in methods of treatment. The amorphous metal-organic framework may hold a component for delivery. The amorphous metal-organic framework is obtained or is obtainable by amorphization of a crystalline amorphous metal-organic framework holding the component. The amorphous metal-organic framework may be a zirconium-containing or a bismuth-containing metal-organic framework, such as a framework having arylcarboxylate ligands, such as benzenedicarboxylate ligands.

Amorphous metal-organic frameworks

This invention relates to solid formulations for the oral delivery of live microbial cells which comprise dried viable cells and small amounts of a bile acid binding agent, for example, an anion exchange resin such as cholestyramine. The presence of bile acid binding agents in the formulation significantly increases the survival of the cells in the intestinal tract and facilitates delivery of the viable cells to the intestine.

Formulations of viable cells for oral delivery

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Cambridge, United Kingdom

Nigel Slater