Syntaxin Limited

The Secretary of State for Health

Secretary of State for Health and Social Care

Nigel Silman

Clifford Charles Shone

John Mark Sutton

Bassam Hallis

Ann Williams

Sajid Javed

Karen Kempsell

Sally Sharpe

Richard Vipond

This invention relates to the detection and diagnosis of tuberculosis. More specifically, the invention relates to new biomarkers and combinations thereof that enable the accurate detection and diagnosis of tuberculosis.

Biomarkers and combinations thereof for diagnosing tuberculosis

A composition for delivery of superoxide dismutase to neuronal cells comprise a superoxide dismutase linked by a linker to a neuronal cell targeting component, which component comprises a first domain that binds to a neuronal cell and a second domain that translocates the superoxide dimutase into the neuronal cell. After translocation, the linker is cleaved to release superoxide dimutase from the neuronal cell targeting domain. Also described is use of the composition for treatment of oxidative damage to neuronal cells and further targeting of the composition using human mitochondrial leader sequences. A hybrid polypeptide is described that contains a bacterial superoxide dismutase plus a sequence that targets a human mitochondira.

Delivery of superoxide dismutase to neuronal cells

A non-toxic polypeptide, for delivery of a therapeutic agent to a neuronal cell, comprises a binding domain that binds to the neuronal cell, and a translocation domain that translocates the therapeutic agent into the neuronal cell, wherein the translocation domain is not a Hdomain of a clostridial toxin and is not a fragment or derivative of a Hdomain of a clostridial toxin.

Constructs for delivery of therapeutic agents to neuronal cells

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Salisbury, United Kingdom

Nigel Silman